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Preparation and Quality Control of the [(153)Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats
Development of lanthanide detoxification agents and protocols is of great importance in management of overdoses. Due to safety of maltol as a detoxifying agent in metal overloads, it can be used as a lanthanide detoxifying agent. In order to demonstrate the biodistribution of final complex, [(153)Sm...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Österreichische Apotheker-Verlagsgesellschaft
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134855/ https://www.ncbi.nlm.nih.gov/pubmed/21773065 http://dx.doi.org/10.3797/scipharm.1011-08 |
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author | Naseri, Zohreh Hakimi, Amir Jalilian, Amir R. Nemati Kharat, Ali Bahrami-Samani, Ali Ghannadi-Maragheh, Mohammad |
author_facet | Naseri, Zohreh Hakimi, Amir Jalilian, Amir R. Nemati Kharat, Ali Bahrami-Samani, Ali Ghannadi-Maragheh, Mohammad |
author_sort | Naseri, Zohreh |
collection | PubMed |
description | Development of lanthanide detoxification agents and protocols is of great importance in management of overdoses. Due to safety of maltol as a detoxifying agent in metal overloads, it can be used as a lanthanide detoxifying agent. In order to demonstrate the biodistribution of final complex, [(153)Sm]-samarium maltolate was prepared using Sm-153 chloride (radiochemical purity >99.9%; ITLC and specific activity). The stability of the labeled compound was determined in the final solution up to 24h as well as the partition coefficient. Biodistribution studies of Sm-153 chloride, [(153)Sm]-samarium maltolate were carried out in wild-type rats comparing the critical organ uptakes. Comparative study for Sm(3+) cation and the labeled compound was conducted up to 48 h, demonstrating a more rapid wash out for the labeled compound. The effective and biological half lives of 2.3 h and 2.46h were calculated for the complex. The data suggest the detoxification property of maltol formulation for lanthanide overdoses. |
format | Online Article Text |
id | pubmed-3134855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Österreichische Apotheker-Verlagsgesellschaft |
record_format | MEDLINE/PubMed |
spelling | pubmed-31348552011-07-19 Preparation and Quality Control of the [(153)Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats Naseri, Zohreh Hakimi, Amir Jalilian, Amir R. Nemati Kharat, Ali Bahrami-Samani, Ali Ghannadi-Maragheh, Mohammad Sci Pharm Research Article Development of lanthanide detoxification agents and protocols is of great importance in management of overdoses. Due to safety of maltol as a detoxifying agent in metal overloads, it can be used as a lanthanide detoxifying agent. In order to demonstrate the biodistribution of final complex, [(153)Sm]-samarium maltolate was prepared using Sm-153 chloride (radiochemical purity >99.9%; ITLC and specific activity). The stability of the labeled compound was determined in the final solution up to 24h as well as the partition coefficient. Biodistribution studies of Sm-153 chloride, [(153)Sm]-samarium maltolate were carried out in wild-type rats comparing the critical organ uptakes. Comparative study for Sm(3+) cation and the labeled compound was conducted up to 48 h, demonstrating a more rapid wash out for the labeled compound. The effective and biological half lives of 2.3 h and 2.46h were calculated for the complex. The data suggest the detoxification property of maltol formulation for lanthanide overdoses. Österreichische Apotheker-Verlagsgesellschaft 2011 2011-02-24 /pmc/articles/PMC3134855/ /pubmed/21773065 http://dx.doi.org/10.3797/scipharm.1011-08 Text en © Naseri et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Naseri, Zohreh Hakimi, Amir Jalilian, Amir R. Nemati Kharat, Ali Bahrami-Samani, Ali Ghannadi-Maragheh, Mohammad Preparation and Quality Control of the [(153)Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats |
title | Preparation and Quality Control of the [(153)Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats |
title_full | Preparation and Quality Control of the [(153)Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats |
title_fullStr | Preparation and Quality Control of the [(153)Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats |
title_full_unstemmed | Preparation and Quality Control of the [(153)Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats |
title_short | Preparation and Quality Control of the [(153)Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats |
title_sort | preparation and quality control of the [(153)sm]-samarium maltolate complex as a lanthanide mobilization product in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134855/ https://www.ncbi.nlm.nih.gov/pubmed/21773065 http://dx.doi.org/10.3797/scipharm.1011-08 |
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