Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease

Oxidative imbalance is one of the earliest manifestations of Alzheimer disease (AD) actually preceding the classic pathology of amyloid β deposits and neurofibrillary tangles. Clinical trials examining antioxidant modulation by a number of global interventions show efficacy, while simple supplementa...

Descripción completa

Detalles Bibliográficos
Autores principales: Clark, Timothy A., Lee, Hyun Pil, Rolston, Raj K., Zhu, Xiongwei, Marlatt, Michael W., Castellani, Rudy J., Nunomura, Akihiko, Casadesus, Gemma, Smith, Mark A., Lee, Hyoung-gon, Perry, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134937/
https://www.ncbi.nlm.nih.gov/pubmed/21765811
_version_ 1782208034380972032
author Clark, Timothy A.
Lee, Hyun Pil
Rolston, Raj K.
Zhu, Xiongwei
Marlatt, Michael W.
Castellani, Rudy J.
Nunomura, Akihiko
Casadesus, Gemma
Smith, Mark A.
Lee, Hyoung-gon
Perry, George
author_facet Clark, Timothy A.
Lee, Hyun Pil
Rolston, Raj K.
Zhu, Xiongwei
Marlatt, Michael W.
Castellani, Rudy J.
Nunomura, Akihiko
Casadesus, Gemma
Smith, Mark A.
Lee, Hyoung-gon
Perry, George
author_sort Clark, Timothy A.
collection PubMed
description Oxidative imbalance is one of the earliest manifestations of Alzheimer disease (AD) actually preceding the classic pathology of amyloid β deposits and neurofibrillary tangles. Clinical trials examining antioxidant modulation by a number of global interventions show efficacy, while simple supplementation has limited benefit suggesting complexity of multiple contributing factors. In this review, we highlight new insights regarding novel approaches to understanding and treating AD based on holistic views of oxidative balance including diet.
format Online
Article
Text
id pubmed-3134937
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Master Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-31349372011-07-13 Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease Clark, Timothy A. Lee, Hyun Pil Rolston, Raj K. Zhu, Xiongwei Marlatt, Michael W. Castellani, Rudy J. Nunomura, Akihiko Casadesus, Gemma Smith, Mark A. Lee, Hyoung-gon Perry, George Int J Biomed Sci Article Oxidative imbalance is one of the earliest manifestations of Alzheimer disease (AD) actually preceding the classic pathology of amyloid β deposits and neurofibrillary tangles. Clinical trials examining antioxidant modulation by a number of global interventions show efficacy, while simple supplementation has limited benefit suggesting complexity of multiple contributing factors. In this review, we highlight new insights regarding novel approaches to understanding and treating AD based on holistic views of oxidative balance including diet. Master Publishing Group 2010-09 /pmc/articles/PMC3134937/ /pubmed/21765811 Text en © Timothy A. Clark et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Clark, Timothy A.
Lee, Hyun Pil
Rolston, Raj K.
Zhu, Xiongwei
Marlatt, Michael W.
Castellani, Rudy J.
Nunomura, Akihiko
Casadesus, Gemma
Smith, Mark A.
Lee, Hyoung-gon
Perry, George
Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease
title Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease
title_full Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease
title_fullStr Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease
title_full_unstemmed Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease
title_short Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease
title_sort oxidative stress and its implications for future treatments and management of alzheimer disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134937/
https://www.ncbi.nlm.nih.gov/pubmed/21765811
work_keys_str_mv AT clarktimothya oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT leehyunpil oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT rolstonrajk oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT zhuxiongwei oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT marlattmichaelw oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT castellanirudyj oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT nunomuraakihiko oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT casadesusgemma oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT smithmarka oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT leehyounggon oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease
AT perrygeorge oxidativestressanditsimplicationsforfuturetreatmentsandmanagementofalzheimerdisease

Ejemplares similares