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Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report
Background. Alpha II antiplasmin is a protein involved in the inhibition of fibrinolysis. A deficiency in this protein leads to increased hemorrhage. It is inherited in an autosomal recessive fashion. Case. 30-year-old Gravida 1, Para 0, presented for prenatal care with her first and subsequently he...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135094/ https://www.ncbi.nlm.nih.gov/pubmed/21765837 http://dx.doi.org/10.1155/2011/698648 |
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author | Dawley, Brenda |
author_facet | Dawley, Brenda |
author_sort | Dawley, Brenda |
collection | PubMed |
description | Background. Alpha II antiplasmin is a protein involved in the inhibition of fibrinolysis. A deficiency in this protein leads to increased hemorrhage. It is inherited in an autosomal recessive fashion. Case. 30-year-old Gravida 1, Para 0, presented for prenatal care with her first and subsequently her second pregnancy. Her medical history was significant for a known deficiency in alpha II antiplasmin. Her first and second pregnancies were complicated by nonobstetrical hemorrhage requiring transfusions and severe preeclampsia requiring preterm deliveries. Conclusion. Alpha II antiplasmin deficiency resulted in multiple episodes of nonobstetrical hemorrhages requiring transfusion and ultimately preterm deliveries due to severe preeclampsia. Both infants and mother had a good outcome. The presence of this disorder may require a multidisciplinary team approach involving obstetricians, pediatricians, and hematologists. Precis. Alpha II antiplasmin deficiency is a rare autosomal recessive disorder leading to increased fibrinolysis and hemorrhage. We present a case report of a pregnancy complicated by this disorder. |
format | Online Article Text |
id | pubmed-3135094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31350942011-07-15 Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report Dawley, Brenda Obstet Gynecol Int Case Report Background. Alpha II antiplasmin is a protein involved in the inhibition of fibrinolysis. A deficiency in this protein leads to increased hemorrhage. It is inherited in an autosomal recessive fashion. Case. 30-year-old Gravida 1, Para 0, presented for prenatal care with her first and subsequently her second pregnancy. Her medical history was significant for a known deficiency in alpha II antiplasmin. Her first and second pregnancies were complicated by nonobstetrical hemorrhage requiring transfusions and severe preeclampsia requiring preterm deliveries. Conclusion. Alpha II antiplasmin deficiency resulted in multiple episodes of nonobstetrical hemorrhages requiring transfusion and ultimately preterm deliveries due to severe preeclampsia. Both infants and mother had a good outcome. The presence of this disorder may require a multidisciplinary team approach involving obstetricians, pediatricians, and hematologists. Precis. Alpha II antiplasmin deficiency is a rare autosomal recessive disorder leading to increased fibrinolysis and hemorrhage. We present a case report of a pregnancy complicated by this disorder. Hindawi Publishing Corporation 2011 2011-05-15 /pmc/articles/PMC3135094/ /pubmed/21765837 http://dx.doi.org/10.1155/2011/698648 Text en Copyright © 2011 Brenda Dawley. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Dawley, Brenda Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report |
title | Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report |
title_full | Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report |
title_fullStr | Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report |
title_full_unstemmed | Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report |
title_short | Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report |
title_sort | alpha ii antiplasmin deficiency complicating pregnancy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135094/ https://www.ncbi.nlm.nih.gov/pubmed/21765837 http://dx.doi.org/10.1155/2011/698648 |
work_keys_str_mv | AT dawleybrenda alphaiiantiplasmindeficiencycomplicatingpregnancyacasereport |