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Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals
Polyphenols of phytochemicals are thought to exhibit chemopreventive effects against cancer. These plant-derived antioxidant polyphenols have a dual nature, also acting as pro-oxidants, generating reactive oxygen species (ROS), and causing oxidative stress. When studying the overall cytotoxicity of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135211/ https://www.ncbi.nlm.nih.gov/pubmed/21776260 http://dx.doi.org/10.1155/2011/467305 |
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author | Babich, Harvey Schuck, Alyssa G. Weisburg, Jeffrey H. Zuckerbraun, Harriet L. |
author_facet | Babich, Harvey Schuck, Alyssa G. Weisburg, Jeffrey H. Zuckerbraun, Harriet L. |
author_sort | Babich, Harvey |
collection | PubMed |
description | Polyphenols of phytochemicals are thought to exhibit chemopreventive effects against cancer. These plant-derived antioxidant polyphenols have a dual nature, also acting as pro-oxidants, generating reactive oxygen species (ROS), and causing oxidative stress. When studying the overall cytotoxicity of polyphenols, research strategies need to distinguish the cytotoxic component derived from the polyphenol per se from that derived from the generated ROS. Such strategies include (a) identifying hallmarks of oxidative damage, such as depletion of intracellular glutathione and lipid peroxidation, (b) classical manipulations, such as polyphenol exposures in the absence and presence of antioxidant enzymes (i.e., catalase and superoxide dismutase) and of antioxidants (e.g., glutathione and N-acetylcysteine) and cotreatments with glutathione depleters, and (c) more recent manipulations, such as divalent cobalt and pyruvate to scavenge ROS. Attention also must be directed to the influence of iron and copper ions and to the level of polyphenols, which mediate oxidative stress. |
format | Online Article Text |
id | pubmed-3135211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31352112011-07-20 Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals Babich, Harvey Schuck, Alyssa G. Weisburg, Jeffrey H. Zuckerbraun, Harriet L. J Toxicol Review Article Polyphenols of phytochemicals are thought to exhibit chemopreventive effects against cancer. These plant-derived antioxidant polyphenols have a dual nature, also acting as pro-oxidants, generating reactive oxygen species (ROS), and causing oxidative stress. When studying the overall cytotoxicity of polyphenols, research strategies need to distinguish the cytotoxic component derived from the polyphenol per se from that derived from the generated ROS. Such strategies include (a) identifying hallmarks of oxidative damage, such as depletion of intracellular glutathione and lipid peroxidation, (b) classical manipulations, such as polyphenol exposures in the absence and presence of antioxidant enzymes (i.e., catalase and superoxide dismutase) and of antioxidants (e.g., glutathione and N-acetylcysteine) and cotreatments with glutathione depleters, and (c) more recent manipulations, such as divalent cobalt and pyruvate to scavenge ROS. Attention also must be directed to the influence of iron and copper ions and to the level of polyphenols, which mediate oxidative stress. Hindawi Publishing Corporation 2011 2011-06-26 /pmc/articles/PMC3135211/ /pubmed/21776260 http://dx.doi.org/10.1155/2011/467305 Text en Copyright © 2011 Harvey Babich et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Babich, Harvey Schuck, Alyssa G. Weisburg, Jeffrey H. Zuckerbraun, Harriet L. Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals |
title | Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals |
title_full | Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals |
title_fullStr | Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals |
title_full_unstemmed | Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals |
title_short | Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals |
title_sort | research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135211/ https://www.ncbi.nlm.nih.gov/pubmed/21776260 http://dx.doi.org/10.1155/2011/467305 |
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