A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy

An efficient formal total synthesis of (±)-clavukerin A was accomplished via a gold-catalyzed cycloisomerization of a 3-methoxy-1,6-enyne 5 as the key strategy followed by Rh-catalyzed stereoselective hydrogenation of the cycloheptenone 4.

Detalles Bibliográficos
Autores principales: Cheong, Jae Youp, Rhee, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135252/
https://www.ncbi.nlm.nih.gov/pubmed/21804869
http://dx.doi.org/10.3762/bjoc.7.84
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author Cheong, Jae Youp
Rhee, Young Ho
author_facet Cheong, Jae Youp
Rhee, Young Ho
author_sort Cheong, Jae Youp
collection PubMed
description An efficient formal total synthesis of (±)-clavukerin A was accomplished via a gold-catalyzed cycloisomerization of a 3-methoxy-1,6-enyne 5 as the key strategy followed by Rh-catalyzed stereoselective hydrogenation of the cycloheptenone 4.
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spelling pubmed-31352522011-07-29 A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy Cheong, Jae Youp Rhee, Young Ho Beilstein J Org Chem Letter An efficient formal total synthesis of (±)-clavukerin A was accomplished via a gold-catalyzed cycloisomerization of a 3-methoxy-1,6-enyne 5 as the key strategy followed by Rh-catalyzed stereoselective hydrogenation of the cycloheptenone 4. Beilstein-Institut 2011-06-01 /pmc/articles/PMC3135252/ /pubmed/21804869 http://dx.doi.org/10.3762/bjoc.7.84 Text en Copyright © 2011, Cheong and Rhee https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Cheong, Jae Youp
Rhee, Young Ho
A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy
title A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy
title_full A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy
title_fullStr A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy
title_full_unstemmed A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy
title_short A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy
title_sort racemic formal total synthesis of clavukerin a using gold(i)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135252/
https://www.ncbi.nlm.nih.gov/pubmed/21804869
http://dx.doi.org/10.3762/bjoc.7.84
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