A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas

Glioblastoma Multiforme (GBM), the most common and lethal primary human brain tumor, exhibits multiple molecular aberrations. We report that loss of the transcription factor GATA4, a negative regulator of normal astrocyte proliferation, is a driver in glioma formation and fulfills the hallmarks of a...

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Detalles Bibliográficos
Autores principales: Agnihotri, Sameer, Wolf, Amparo, Munoz, Diana M., Smith, Christopher J., Gajadhar, Aaron, Restrepo, Andres, Clarke, Ian D., Fuller, Gregory N., Kesari, Santosh, Dirks, Peter B., McGlade, C. Jane, Stanford, William L., Aldape, Kenneth, Mischel, Paul S., Hawkins, Cynthia, Guha, Abhijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135351/
https://www.ncbi.nlm.nih.gov/pubmed/21464220
http://dx.doi.org/10.1084/jem.20102099

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