Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL

The NOTCH1 signaling pathway is a critical determinant of cell fate decisions and drives oncogenesis through mechanisms that are incompletely understood. Using an established mouse model of T cell acute lymphoblastic leukemia (T-ALL), here we report that induction of intracellular Notch1 (ICN1) lead...

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Detalles Bibliográficos
Autores principales: Li, Xiaoyu, Sanda, Takaomi, Look, A. Thomas, Novina, Carl D., von Boehmer, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135352/
https://www.ncbi.nlm.nih.gov/pubmed/21464222
http://dx.doi.org/10.1084/jem.20102384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135352/
https://www.ncbi.nlm.nih.gov/pubmed/21464222
http://dx.doi.org/10.1084/jem.20102384

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