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Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL
The NOTCH1 signaling pathway is a critical determinant of cell fate decisions and drives oncogenesis through mechanisms that are incompletely understood. Using an established mouse model of T cell acute lymphoblastic leukemia (T-ALL), here we report that induction of intracellular Notch1 (ICN1) lead...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135352/ https://www.ncbi.nlm.nih.gov/pubmed/21464222 http://dx.doi.org/10.1084/jem.20102384 |