CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway

CIN85, an adaptor protein which binds the C-terminal domain of tyrosine phosphorylated Cbl and Cbl-b, has been thought to be involved in the internalization and subsequent degradation of receptors. However, its physiological function remains unclear. To determine its role in B cells, we used Mb1-cre...

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Detalles Bibliográficos
Autores principales: Kometani, Kohei, Yamada, Takayuki, Sasaki, Yoshiteru, Yokosuka, Tadashi, Saito, Takashi, Rajewsky, Klaus, Ishiai, Masamichi, Hikida, Masaki, Kurosaki, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135365/
https://www.ncbi.nlm.nih.gov/pubmed/21708930
http://dx.doi.org/10.1084/jem.20102665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135365/
https://www.ncbi.nlm.nih.gov/pubmed/21708930
http://dx.doi.org/10.1084/jem.20102665

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