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Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope

Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic β cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A(g7) molecules of nonobese diabetic (N...

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Detalles Bibliográficos
Autores principales:	Daniel, Carolin, Weigmann, Benno, Bronson, Roderick, von Boehmer, Harald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135372/ https://www.ncbi.nlm.nih.gov/pubmed/21690251 http://dx.doi.org/10.1084/jem.20110574

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