Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5×10(−20)), transferrin saturation (combined P = 2.2×10(−23)), and erythrocyte mean cell volume (MCV, combined P = 1.1×10(−10)). We also find suggestive evi...

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Autores principales: Benyamin, Beben, Ferreira, Manuel A. R., Willemsen, Gonneke, Gordon, Scott, Middelberg, Rita P. S., McEvoy, Brian P., Hottenga, Jouke-Jan, Henders, Anjali K., Campbell, Megan J., Wallace, Leanne, Frazer, Ian H., Heath, Andrew C., de Geus, Eco J. C., Nyholt, Dale R., Visscher, Peter M., Penninx, Brenda W., Boomsma, Dorret I., Martin, Nicholas G., Montgomery, Grant W., Whitfield, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135421/
https://www.ncbi.nlm.nih.gov/pubmed/19820699
http://dx.doi.org/10.1038/ng.456
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author Benyamin, Beben
Ferreira, Manuel A. R.
Willemsen, Gonneke
Gordon, Scott
Middelberg, Rita P. S.
McEvoy, Brian P.
Hottenga, Jouke-Jan
Henders, Anjali K.
Campbell, Megan J.
Wallace, Leanne
Frazer, Ian H.
Heath, Andrew C.
de Geus, Eco J. C.
Nyholt, Dale R.
Visscher, Peter M.
Penninx, Brenda W.
Boomsma, Dorret I.
Martin, Nicholas G.
Montgomery, Grant W.
Whitfield, John B.
author_facet Benyamin, Beben
Ferreira, Manuel A. R.
Willemsen, Gonneke
Gordon, Scott
Middelberg, Rita P. S.
McEvoy, Brian P.
Hottenga, Jouke-Jan
Henders, Anjali K.
Campbell, Megan J.
Wallace, Leanne
Frazer, Ian H.
Heath, Andrew C.
de Geus, Eco J. C.
Nyholt, Dale R.
Visscher, Peter M.
Penninx, Brenda W.
Boomsma, Dorret I.
Martin, Nicholas G.
Montgomery, Grant W.
Whitfield, John B.
author_sort Benyamin, Beben
collection PubMed
description We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5×10(−20)), transferrin saturation (combined P = 2.2×10(−23)), and erythrocyte mean cell volume (MCV, combined P = 1.1×10(−10)). We also find suggestive evidence of association with blood haemoglobin levels (combined P = 5.3×10(−7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.
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spelling pubmed-31354212011-07-13 Common variants in TMPRSS6 are associated with iron status and erythrocyte volume Benyamin, Beben Ferreira, Manuel A. R. Willemsen, Gonneke Gordon, Scott Middelberg, Rita P. S. McEvoy, Brian P. Hottenga, Jouke-Jan Henders, Anjali K. Campbell, Megan J. Wallace, Leanne Frazer, Ian H. Heath, Andrew C. de Geus, Eco J. C. Nyholt, Dale R. Visscher, Peter M. Penninx, Brenda W. Boomsma, Dorret I. Martin, Nicholas G. Montgomery, Grant W. Whitfield, John B. Nat Genet Article We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5×10(−20)), transferrin saturation (combined P = 2.2×10(−23)), and erythrocyte mean cell volume (MCV, combined P = 1.1×10(−10)). We also find suggestive evidence of association with blood haemoglobin levels (combined P = 5.3×10(−7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. 2009-10-11 2009-11 /pmc/articles/PMC3135421/ /pubmed/19820699 http://dx.doi.org/10.1038/ng.456 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Benyamin, Beben
Ferreira, Manuel A. R.
Willemsen, Gonneke
Gordon, Scott
Middelberg, Rita P. S.
McEvoy, Brian P.
Hottenga, Jouke-Jan
Henders, Anjali K.
Campbell, Megan J.
Wallace, Leanne
Frazer, Ian H.
Heath, Andrew C.
de Geus, Eco J. C.
Nyholt, Dale R.
Visscher, Peter M.
Penninx, Brenda W.
Boomsma, Dorret I.
Martin, Nicholas G.
Montgomery, Grant W.
Whitfield, John B.
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
title Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
title_full Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
title_fullStr Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
title_full_unstemmed Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
title_short Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
title_sort common variants in tmprss6 are associated with iron status and erythrocyte volume
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135421/
https://www.ncbi.nlm.nih.gov/pubmed/19820699
http://dx.doi.org/10.1038/ng.456
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