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A mechanism of Rap1-induced stabilization of endothelial cell–cell junctions

Activation of Rap1 small GTPases stabilizes cell–cell junctions, and this activity requires Krev Interaction Trapped gene 1 (KRIT1). Loss of KRIT1 disrupts cardiovascular development and causes autosomal dominant familial cerebral cavernous malformations. Here we report that native KRIT1 protein bin...

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Detalles Bibliográficos
Autores principales:	Liu, Jian J., Stockton, Rebecca A., Gingras, Alexandre R., Ablooglu, Ararat J., Han, Jaewon, Bobkov, Andrey A., Ginsberg, Mark H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135476/ https://www.ncbi.nlm.nih.gov/pubmed/21633110 http://dx.doi.org/10.1091/mbc.E11-02-0157

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