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Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism
BACKGROUND: Pregnancy in patients with Parkinson disease is a rare occurrence. To the best of our knowledge, the effect of pregnancy as well as treatment in genetically confirmed autosomal recessive juvenile parkinsonism (ARJP) has never been reported. Here, we report the first case of pregnancy in...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135525/ https://www.ncbi.nlm.nih.gov/pubmed/21682904 http://dx.doi.org/10.1186/1471-2377-11-72 |
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author | Serikawa, Takehiro Shimohata, Takayoshi Akashi, Mami Yokoseki, Akio Tsuchiya, Miwa Hasegawa, Arika Haino, Kazufumi Koike, Ryoko Takakuwa, Koichi Tanaka, Keiko Tanaka, Kenichi Nishizawa, Masatoyo |
author_facet | Serikawa, Takehiro Shimohata, Takayoshi Akashi, Mami Yokoseki, Akio Tsuchiya, Miwa Hasegawa, Arika Haino, Kazufumi Koike, Ryoko Takakuwa, Koichi Tanaka, Keiko Tanaka, Kenichi Nishizawa, Masatoyo |
author_sort | Serikawa, Takehiro |
collection | PubMed |
description | BACKGROUND: Pregnancy in patients with Parkinson disease is a rare occurrence. To the best of our knowledge, the effect of pregnancy as well as treatment in genetically confirmed autosomal recessive juvenile parkinsonism (ARJP) has never been reported. Here, we report the first case of pregnancy in a patient with ARJP associated with a parkin gene mutation, ARJP/PARK2. CASE PRESENTATION: A 27-year-old woman with ARJP/PARK2 was diagnosed as having a spontaneous dichorionic/diamniotic twin pregnancy. Exacerbation of motor disability was noted between ovulation and menstruation before pregnancy as well as during late pregnancy, suggesting that her parkinsonism might have been influenced by fluctuations in the levels of endogenous sex hormones. During the organogenesis period, she was only treated with levodopa/carbidopa, although she continued to receive inpatient hospital care for assistance in the activities of daily living. After the organogenesis period, she was administered sufficient amounts of antiparkinsonian drugs. She delivered healthy male twins, and psychomotor development of both the babies was normal at the age of 2 years. CONCLUSION: Pregnancy may worsen the symptoms of ARJP/PARK2, although appropriate treatments with antiparkinsonian drugs and adequate assistance in the activities of daily living might enable successful pregnancy and birth of healthy children. |
format | Online Article Text |
id | pubmed-3135525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31355252011-07-14 Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism Serikawa, Takehiro Shimohata, Takayoshi Akashi, Mami Yokoseki, Akio Tsuchiya, Miwa Hasegawa, Arika Haino, Kazufumi Koike, Ryoko Takakuwa, Koichi Tanaka, Keiko Tanaka, Kenichi Nishizawa, Masatoyo BMC Neurol Case Report BACKGROUND: Pregnancy in patients with Parkinson disease is a rare occurrence. To the best of our knowledge, the effect of pregnancy as well as treatment in genetically confirmed autosomal recessive juvenile parkinsonism (ARJP) has never been reported. Here, we report the first case of pregnancy in a patient with ARJP associated with a parkin gene mutation, ARJP/PARK2. CASE PRESENTATION: A 27-year-old woman with ARJP/PARK2 was diagnosed as having a spontaneous dichorionic/diamniotic twin pregnancy. Exacerbation of motor disability was noted between ovulation and menstruation before pregnancy as well as during late pregnancy, suggesting that her parkinsonism might have been influenced by fluctuations in the levels of endogenous sex hormones. During the organogenesis period, she was only treated with levodopa/carbidopa, although she continued to receive inpatient hospital care for assistance in the activities of daily living. After the organogenesis period, she was administered sufficient amounts of antiparkinsonian drugs. She delivered healthy male twins, and psychomotor development of both the babies was normal at the age of 2 years. CONCLUSION: Pregnancy may worsen the symptoms of ARJP/PARK2, although appropriate treatments with antiparkinsonian drugs and adequate assistance in the activities of daily living might enable successful pregnancy and birth of healthy children. BioMed Central 2011-06-17 /pmc/articles/PMC3135525/ /pubmed/21682904 http://dx.doi.org/10.1186/1471-2377-11-72 Text en Copyright ©2011 Serikawa et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Serikawa, Takehiro Shimohata, Takayoshi Akashi, Mami Yokoseki, Akio Tsuchiya, Miwa Hasegawa, Arika Haino, Kazufumi Koike, Ryoko Takakuwa, Koichi Tanaka, Keiko Tanaka, Kenichi Nishizawa, Masatoyo Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism |
title | Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism |
title_full | Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism |
title_fullStr | Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism |
title_full_unstemmed | Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism |
title_short | Successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism |
title_sort | successful twin pregnancy in a patient with parkin-associated autosomal recessive juvenile parkinsonism |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135525/ https://www.ncbi.nlm.nih.gov/pubmed/21682904 http://dx.doi.org/10.1186/1471-2377-11-72 |
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