Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts

Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays usi...

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Autores principales: Calvo, Tamara Regina, Cardoso, Cássia Regina Primila, da Silva Moura, Adriana Candido, dos Santos, Lourdes Campaner, Colus, Ilce Mara Syllos, Vilegas, Wagner, Varanda, Eliana Aparecida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
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Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135973/
https://www.ncbi.nlm.nih.gov/pubmed/19696193
http://dx.doi.org/10.1093/ecam/nep123
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author Calvo, Tamara Regina
Cardoso, Cássia Regina Primila
da Silva Moura, Adriana Candido
dos Santos, Lourdes Campaner
Colus, Ilce Mara Syllos
Vilegas, Wagner
Varanda, Eliana Aparecida
author_facet Calvo, Tamara Regina
Cardoso, Cássia Regina Primila
da Silva Moura, Adriana Candido
dos Santos, Lourdes Campaner
Colus, Ilce Mara Syllos
Vilegas, Wagner
Varanda, Eliana Aparecida
author_sort Calvo, Tamara Regina
collection PubMed
description Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.
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spelling pubmed-31359732011-07-20 Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts Calvo, Tamara Regina Cardoso, Cássia Regina Primila da Silva Moura, Adriana Candido dos Santos, Lourdes Campaner Colus, Ilce Mara Syllos Vilegas, Wagner Varanda, Eliana Aparecida Evid Based Complement Alternat Med Original Article Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity. Hindawi Publishing Corporation 2011 2011-02-17 /pmc/articles/PMC3135973/ /pubmed/19696193 http://dx.doi.org/10.1093/ecam/nep123 Text en Copyright © 2011 Tamara Regina Calvo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Calvo, Tamara Regina
Cardoso, Cássia Regina Primila
da Silva Moura, Adriana Candido
dos Santos, Lourdes Campaner
Colus, Ilce Mara Syllos
Vilegas, Wagner
Varanda, Eliana Aparecida
Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_full Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_fullStr Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_full_unstemmed Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_short Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
title_sort mutagenic activity of indigofera truxillensis and i. suffruticosa aerial parts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135973/
https://www.ncbi.nlm.nih.gov/pubmed/19696193
http://dx.doi.org/10.1093/ecam/nep123
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