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Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel

Neurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory. Hibernation in Siberian ground squirrels provides a natural model to study mitosis as the rapid fall in body temperature in 24 h (from 35-36°C to +4–6°C) permits accumulation of mitotic c...

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Detalles Bibliográficos
Autores principales: Popov, Victor I., Kraev, Igor V., Ignat'ev, Dmitri A., Stewart, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136081/
https://www.ncbi.nlm.nih.gov/pubmed/21773054
http://dx.doi.org/10.1155/2011/867525
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author Popov, Victor I.
Kraev, Igor V.
Ignat'ev, Dmitri A.
Stewart, Michael G.
author_facet Popov, Victor I.
Kraev, Igor V.
Ignat'ev, Dmitri A.
Stewart, Michael G.
author_sort Popov, Victor I.
collection PubMed
description Neurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory. Hibernation in Siberian ground squirrels provides a natural model to study mitosis as the rapid fall in body temperature in 24 h (from 35-36°C to +4–6°C) permits accumulation of mitotic cells at different stages of the cell cycle. Histological methods used to study adult neurogenesis are limited largely to fixed tissue, and the mitotic state elucidated depends on the specific phase of mitosis at the time of day. However, using an immunohistochemical study of doublecortin (DCX) and BrdU-labelled neurons, we demonstrate that the dentate gyrus of the ground squirrel hippocampus contains a population of immature cells which appear to possess mitotic activity. Our data suggest that doublecortin-labelled immature cells exist in a mitotic state and may represent a renewable pool for generation of new neurons within the dentate gyrus.
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spelling pubmed-31360812011-07-19 Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel Popov, Victor I. Kraev, Igor V. Ignat'ev, Dmitri A. Stewart, Michael G. Neural Plast Research Article Neurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory. Hibernation in Siberian ground squirrels provides a natural model to study mitosis as the rapid fall in body temperature in 24 h (from 35-36°C to +4–6°C) permits accumulation of mitotic cells at different stages of the cell cycle. Histological methods used to study adult neurogenesis are limited largely to fixed tissue, and the mitotic state elucidated depends on the specific phase of mitosis at the time of day. However, using an immunohistochemical study of doublecortin (DCX) and BrdU-labelled neurons, we demonstrate that the dentate gyrus of the ground squirrel hippocampus contains a population of immature cells which appear to possess mitotic activity. Our data suggest that doublecortin-labelled immature cells exist in a mitotic state and may represent a renewable pool for generation of new neurons within the dentate gyrus. Hindawi Publishing Corporation 2011 2011-05-15 /pmc/articles/PMC3136081/ /pubmed/21773054 http://dx.doi.org/10.1155/2011/867525 Text en Copyright © 2011 Victor I. Popov et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Popov, Victor I.
Kraev, Igor V.
Ignat'ev, Dmitri A.
Stewart, Michael G.
Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel
title Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel
title_full Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel
title_fullStr Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel
title_full_unstemmed Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel
title_short Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel
title_sort suspension of mitotic activity in dentate gyrus of the hibernating ground squirrel
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136081/
https://www.ncbi.nlm.nih.gov/pubmed/21773054
http://dx.doi.org/10.1155/2011/867525
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