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Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, whic...

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Autores principales: Curti, Maira Ladeia R., Jacob, Patrícia, Borges, Maria Carolina, Rogero, Marcelo Macedo, Ferreira, Sandra Roberta G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136190/
https://www.ncbi.nlm.nih.gov/pubmed/21773006
http://dx.doi.org/10.1155/2011/497401
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author Curti, Maira Ladeia R.
Jacob, Patrícia
Borges, Maria Carolina
Rogero, Marcelo Macedo
Ferreira, Sandra Roberta G.
author_facet Curti, Maira Ladeia R.
Jacob, Patrícia
Borges, Maria Carolina
Rogero, Marcelo Macedo
Ferreira, Sandra Roberta G.
author_sort Curti, Maira Ladeia R.
collection PubMed
description Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, which are well-known risk factors for cardiovascular disease. Furthermore, there is evidence that genetic variation that predisposes to inflammation and metabolic disturbances could interact with environmental factors, such as diet, modulating individual susceptibility to developing these conditions. This paper aims to review the possible interactions between diet and single-nucleotide polymorphisms (SNPs) in genes implicated on the inflammatory response, lipoprotein metabolism, and oxidative status. Therefore, the impact of genetic variants of the peroxisome proliferator-activated receptor-(PPAR-)gamma, tumor necrosis factor-(TNF-)alpha, interleukin (IL)-1, IL-6, apolipoprotein (Apo) A1, Apo A2, Apo A5, Apo E, glutathione peroxidases 1, 2, and 4, and selenoprotein P exposed to variations on diet composition is described.
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spelling pubmed-31361902011-07-19 Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach Curti, Maira Ladeia R. Jacob, Patrícia Borges, Maria Carolina Rogero, Marcelo Macedo Ferreira, Sandra Roberta G. J Obes Review Article Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, which are well-known risk factors for cardiovascular disease. Furthermore, there is evidence that genetic variation that predisposes to inflammation and metabolic disturbances could interact with environmental factors, such as diet, modulating individual susceptibility to developing these conditions. This paper aims to review the possible interactions between diet and single-nucleotide polymorphisms (SNPs) in genes implicated on the inflammatory response, lipoprotein metabolism, and oxidative status. Therefore, the impact of genetic variants of the peroxisome proliferator-activated receptor-(PPAR-)gamma, tumor necrosis factor-(TNF-)alpha, interleukin (IL)-1, IL-6, apolipoprotein (Apo) A1, Apo A2, Apo A5, Apo E, glutathione peroxidases 1, 2, and 4, and selenoprotein P exposed to variations on diet composition is described. Hindawi Publishing Corporation 2011 2011-05-23 /pmc/articles/PMC3136190/ /pubmed/21773006 http://dx.doi.org/10.1155/2011/497401 Text en Copyright © 2011 Maira Ladeia R. Curti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Curti, Maira Ladeia R.
Jacob, Patrícia
Borges, Maria Carolina
Rogero, Marcelo Macedo
Ferreira, Sandra Roberta G.
Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach
title Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach
title_full Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach
title_fullStr Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach
title_full_unstemmed Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach
title_short Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach
title_sort studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136190/
https://www.ncbi.nlm.nih.gov/pubmed/21773006
http://dx.doi.org/10.1155/2011/497401
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