Cargando…
Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach
Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, whic...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136190/ https://www.ncbi.nlm.nih.gov/pubmed/21773006 http://dx.doi.org/10.1155/2011/497401 |
_version_ | 1782208184710070272 |
---|---|
author | Curti, Maira Ladeia R. Jacob, Patrícia Borges, Maria Carolina Rogero, Marcelo Macedo Ferreira, Sandra Roberta G. |
author_facet | Curti, Maira Ladeia R. Jacob, Patrícia Borges, Maria Carolina Rogero, Marcelo Macedo Ferreira, Sandra Roberta G. |
author_sort | Curti, Maira Ladeia R. |
collection | PubMed |
description | Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, which are well-known risk factors for cardiovascular disease. Furthermore, there is evidence that genetic variation that predisposes to inflammation and metabolic disturbances could interact with environmental factors, such as diet, modulating individual susceptibility to developing these conditions. This paper aims to review the possible interactions between diet and single-nucleotide polymorphisms (SNPs) in genes implicated on the inflammatory response, lipoprotein metabolism, and oxidative status. Therefore, the impact of genetic variants of the peroxisome proliferator-activated receptor-(PPAR-)gamma, tumor necrosis factor-(TNF-)alpha, interleukin (IL)-1, IL-6, apolipoprotein (Apo) A1, Apo A2, Apo A5, Apo E, glutathione peroxidases 1, 2, and 4, and selenoprotein P exposed to variations on diet composition is described. |
format | Online Article Text |
id | pubmed-3136190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31361902011-07-19 Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach Curti, Maira Ladeia R. Jacob, Patrícia Borges, Maria Carolina Rogero, Marcelo Macedo Ferreira, Sandra Roberta G. J Obes Review Article Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, which are well-known risk factors for cardiovascular disease. Furthermore, there is evidence that genetic variation that predisposes to inflammation and metabolic disturbances could interact with environmental factors, such as diet, modulating individual susceptibility to developing these conditions. This paper aims to review the possible interactions between diet and single-nucleotide polymorphisms (SNPs) in genes implicated on the inflammatory response, lipoprotein metabolism, and oxidative status. Therefore, the impact of genetic variants of the peroxisome proliferator-activated receptor-(PPAR-)gamma, tumor necrosis factor-(TNF-)alpha, interleukin (IL)-1, IL-6, apolipoprotein (Apo) A1, Apo A2, Apo A5, Apo E, glutathione peroxidases 1, 2, and 4, and selenoprotein P exposed to variations on diet composition is described. Hindawi Publishing Corporation 2011 2011-05-23 /pmc/articles/PMC3136190/ /pubmed/21773006 http://dx.doi.org/10.1155/2011/497401 Text en Copyright © 2011 Maira Ladeia R. Curti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Curti, Maira Ladeia R. Jacob, Patrícia Borges, Maria Carolina Rogero, Marcelo Macedo Ferreira, Sandra Roberta G. Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach |
title | Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach |
title_full | Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach |
title_fullStr | Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach |
title_full_unstemmed | Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach |
title_short | Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach |
title_sort | studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136190/ https://www.ncbi.nlm.nih.gov/pubmed/21773006 http://dx.doi.org/10.1155/2011/497401 |
work_keys_str_mv | AT curtimairaladeiar studiesofgenevariantsrelatedtoinflammationoxidativestressdyslipidemiaandobesityimplicationsforanutrigeneticapproach AT jacobpatricia studiesofgenevariantsrelatedtoinflammationoxidativestressdyslipidemiaandobesityimplicationsforanutrigeneticapproach AT borgesmariacarolina studiesofgenevariantsrelatedtoinflammationoxidativestressdyslipidemiaandobesityimplicationsforanutrigeneticapproach AT rogeromarcelomacedo studiesofgenevariantsrelatedtoinflammationoxidativestressdyslipidemiaandobesityimplicationsforanutrigeneticapproach AT ferreirasandrarobertag studiesofgenevariantsrelatedtoinflammationoxidativestressdyslipidemiaandobesityimplicationsforanutrigeneticapproach |