Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA

Replication protein A (RPA), a key player in DNA metabolism, has 6 single-stranded DNA-(ssDNA-) binding domains (DBDs) A-F. SELEX experiments with the DBDs-C, -D, and -E retrieve a 20-nt G-quadruplex forming sequence. Binding studies show that RPA-DE binds preferentially to the G-quadruplex DNA, a u...

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Detalles Bibliográficos
Autores principales: Prakash, Aishwarya, Natarajan, Amarnath, Marky, Luis A., Ouellette, Michel M., Borgstahl, Gloria E. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136212/
https://www.ncbi.nlm.nih.gov/pubmed/21772997
http://dx.doi.org/10.4061/2011/896947

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