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The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination
RAD51 recombinase polymerizes at the site of double-strand breaks (DSBs) where it performs DSB repair. The loss of RAD51 causes extensive chromosomal breaks, leading to apoptosis. The polymerization of RAD51 is regulated by a number of RAD51 mediators, such as BRCA1, BRCA2, RAD52, SFR1, SWS1, and th...
Autores principales: | Qing, Yong, Yamazoe, Mitsuyoshi, Hirota, Kouji, Dejsuphong, Donniphat, Sakai, Wataru, Yamamoto, Kimiyo N., Bishop, Douglas K., Wu, XiaoHua, Takeda, Shunichi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136442/ https://www.ncbi.nlm.nih.gov/pubmed/21779174 http://dx.doi.org/10.1371/journal.pgen.1002148 |
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