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Dissociation of Infectivity from Seeding Ability in Prions with Alternate Docking Mechanism
Previous studies identified two mammalian prion protein (PrP) polybasic domains that bind the disease-associated conformer PrP(Sc), suggesting that these domains of cellular prion protein (PrP(C)) serve as docking sites for PrP(Sc) during prion propagation. To examine the role of polybasic domains i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136465/ https://www.ncbi.nlm.nih.gov/pubmed/21779169 http://dx.doi.org/10.1371/journal.ppat.1002128 |