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Activation of Akt by the Bacterial Inositol Phosphatase, SopB, is Wortmannin Insensitive
Salmonella enterica uses effector proteins translocated by a Type III Secretion System to invade epithelial cells. One of the invasion-associated effectors, SopB, is an inositol phosphatase that mediates sustained activation of the pro-survival kinase Akt in infected cells. Canonical activation of A...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136525/ https://www.ncbi.nlm.nih.gov/pubmed/21779406 http://dx.doi.org/10.1371/journal.pone.0022260 |