Cargando…
A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment
The objectives here are to provide a systematic review of the current evidence concerning the use of Chinese herbs in the treatment of Alzheimer's disease (AD) and to understand their mechanisms of action with respect to the pathophysiology of the disease. AD, characterized microscopically by d...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136754/ https://www.ncbi.nlm.nih.gov/pubmed/19737808 http://dx.doi.org/10.1093/ecam/nep136 |
_version_ | 1782208241587978240 |
---|---|
author | Fu, Li-Min Li, Ju-Tzu |
author_facet | Fu, Li-Min Li, Ju-Tzu |
author_sort | Fu, Li-Min |
collection | PubMed |
description | The objectives here are to provide a systematic review of the current evidence concerning the use of Chinese herbs in the treatment of Alzheimer's disease (AD) and to understand their mechanisms of action with respect to the pathophysiology of the disease. AD, characterized microscopically by deposition of amyloid plaques and formation of neurofibrillary tangles in the brain, has become the most common cause of senile dementia. The limitations of western medications have led us to explore herbal medicine. In particular, many Chinese herbs have demonstrated some interesting therapeutic properties. The following databases were searched from their inception: MEDLINE (PUBMED), ALT HEALTH WATCH (EBSCO), CINAH and Cochrane Central. Only single Chinese herbs are included. Two reviewers independently extracted the data and performed quality assessment. The quality assessment of a clinical trial is based on the Jadad criteria. Seven Chinese herbs and six randomized controlled clinical trials were identified under the predefined criteria. Ginkgo biloba, Huperzine A (Lycopodium serratum) and Ginseng have been assessed for their clinical efficacy with limited favorable evidence. No serious adverse events were reported. Chinese herbs show promise in the treatment of AD in terms of their cognitive benefits and more importantly, their mechanisms of action that deal with the fundamental pathophysiology of the disease. However, the current evidence in support of their use is inconclusive or inadequate. Future research should place emphasis on herbs that can treat the root of the disease. |
format | Online Article Text |
id | pubmed-3136754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31367542011-07-28 A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment Fu, Li-Min Li, Ju-Tzu Evid Based Complement Alternat Med Review Article The objectives here are to provide a systematic review of the current evidence concerning the use of Chinese herbs in the treatment of Alzheimer's disease (AD) and to understand their mechanisms of action with respect to the pathophysiology of the disease. AD, characterized microscopically by deposition of amyloid plaques and formation of neurofibrillary tangles in the brain, has become the most common cause of senile dementia. The limitations of western medications have led us to explore herbal medicine. In particular, many Chinese herbs have demonstrated some interesting therapeutic properties. The following databases were searched from their inception: MEDLINE (PUBMED), ALT HEALTH WATCH (EBSCO), CINAH and Cochrane Central. Only single Chinese herbs are included. Two reviewers independently extracted the data and performed quality assessment. The quality assessment of a clinical trial is based on the Jadad criteria. Seven Chinese herbs and six randomized controlled clinical trials were identified under the predefined criteria. Ginkgo biloba, Huperzine A (Lycopodium serratum) and Ginseng have been assessed for their clinical efficacy with limited favorable evidence. No serious adverse events were reported. Chinese herbs show promise in the treatment of AD in terms of their cognitive benefits and more importantly, their mechanisms of action that deal with the fundamental pathophysiology of the disease. However, the current evidence in support of their use is inconclusive or inadequate. Future research should place emphasis on herbs that can treat the root of the disease. Hindawi Publishing Corporation 2011 2011-02-13 /pmc/articles/PMC3136754/ /pubmed/19737808 http://dx.doi.org/10.1093/ecam/nep136 Text en Copyright © 2011 L.-M. Fu and J.-T. Li. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fu, Li-Min Li, Ju-Tzu A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment |
title | A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment |
title_full | A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment |
title_fullStr | A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment |
title_full_unstemmed | A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment |
title_short | A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment |
title_sort | systematic review of single chinese herbs for alzheimer's disease treatment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136754/ https://www.ncbi.nlm.nih.gov/pubmed/19737808 http://dx.doi.org/10.1093/ecam/nep136 |
work_keys_str_mv | AT fulimin asystematicreviewofsinglechineseherbsforalzheimersdiseasetreatment AT lijutzu asystematicreviewofsinglechineseherbsforalzheimersdiseasetreatment AT fulimin systematicreviewofsinglechineseherbsforalzheimersdiseasetreatment AT lijutzu systematicreviewofsinglechineseherbsforalzheimersdiseasetreatment |