Clinical Microfluidics for Neutrophil Genomics and Proteomics

Neutrophils play critical roles in modulating the immune response. We present a robust methodology for rapidly isolating neutrophils directly from whole blood and develop ‘on-chip’ processing for mRNA and protein isolation for genomics and proteomics. We validate this device with an ex vivo stimulat...

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Detalles Bibliográficos
Autores principales: Kotz, Kenneth T., Xiao, Wenzong, Miller-Graziano, Carol, Qian, Wei-Jun, Russom, Aman, Warner, Elizabeth A., Moldawer, Lyle L., De, Asit, Bankey, Paul E., Petritis, Brianne O., Camp, David G., Rosenbach, Alan E., Goverman, Jeremy, Fagan, Shawn P., Brownstein, Bernard H., Irimia, Daniel, Xu, Weihong, Wilhelmy, Julie, Mindrinos, Michael N., Smith, Richard D., Davis, Ronald W., Tompkins, Ronald G., Toner, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136804/
https://www.ncbi.nlm.nih.gov/pubmed/20802500
http://dx.doi.org/10.1038/nm.2205

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