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DNA Vaccines against Dengue Virus Type 2 Based on Truncate Envelope Protein or Its Domain III
Two DNA vaccines were constructed encoding the ectodomain (domains I, II and III) of the DENV2 envelope protein (pE1D2) or only its domain III (pE2D2), fused to the human tissue plasminogen activator signal peptide (t-PA). The expression and secretion of recombinant proteins was confirmed in vitro i...
Autores principales: | Azevedo, Adriana S., Yamamura, Anna M. Y., Freire, Marcos S., Trindade, Gisela F., Bonaldo, Myrna, Galler, Ricardo, Alves, Ada M. B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136928/ https://www.ncbi.nlm.nih.gov/pubmed/21779317 http://dx.doi.org/10.1371/journal.pone.0020528 |
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