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Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence

Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In add...

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Autores principales: Kishi, Taro, Kitajima, Tsuyoshi, Kawashima, Kunihiro, Okochi, Tomo, Yamanouchi, Yoshio, Kinoshita, Yoko, Ujike, Hiroshi, Inada, Toshiya, Yamada, Mitsuhiko, Uchimura, Naohisa, Sora, Ichiro, Iyo, Masaomi, Ozaki, Norio, Iwata, Nakao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137167/
https://www.ncbi.nlm.nih.gov/pubmed/21886577
http://dx.doi.org/10.2174/157015911795017065
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author Kishi, Taro
Kitajima, Tsuyoshi
Kawashima, Kunihiro
Okochi, Tomo
Yamanouchi, Yoshio
Kinoshita, Yoko
Ujike, Hiroshi
Inada, Toshiya
Yamada, Mitsuhiko
Uchimura, Naohisa
Sora, Ichiro
Iyo, Masaomi
Ozaki, Norio
Iwata, Nakao
author_facet Kishi, Taro
Kitajima, Tsuyoshi
Kawashima, Kunihiro
Okochi, Tomo
Yamanouchi, Yoshio
Kinoshita, Yoko
Ujike, Hiroshi
Inada, Toshiya
Yamada, Mitsuhiko
Uchimura, Naohisa
Sora, Ichiro
Iyo, Masaomi
Ozaki, Norio
Iwata, Nakao
author_sort Kishi, Taro
collection PubMed
description Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between NR1D1 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with three tagging SNPs selected by HapMap database. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between NR1D1 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population.
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spelling pubmed-31371672011-09-01 Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence Kishi, Taro Kitajima, Tsuyoshi Kawashima, Kunihiro Okochi, Tomo Yamanouchi, Yoshio Kinoshita, Yoko Ujike, Hiroshi Inada, Toshiya Yamada, Mitsuhiko Uchimura, Naohisa Sora, Ichiro Iyo, Masaomi Ozaki, Norio Iwata, Nakao Curr Neuropharmacol Article Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between NR1D1 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with three tagging SNPs selected by HapMap database. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between NR1D1 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population. Bentham Science Publishers Ltd 2011-03 /pmc/articles/PMC3137167/ /pubmed/21886577 http://dx.doi.org/10.2174/157015911795017065 Text en ©2011 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Kishi, Taro
Kitajima, Tsuyoshi
Kawashima, Kunihiro
Okochi, Tomo
Yamanouchi, Yoshio
Kinoshita, Yoko
Ujike, Hiroshi
Inada, Toshiya
Yamada, Mitsuhiko
Uchimura, Naohisa
Sora, Ichiro
Iyo, Masaomi
Ozaki, Norio
Iwata, Nakao
Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence
title Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence
title_full Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence
title_fullStr Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence
title_full_unstemmed Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence
title_short Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence
title_sort association analysis of nuclear receptor rev-erb alpha gene (nr1d1) and japanese methamphetamine dependence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137167/
https://www.ncbi.nlm.nih.gov/pubmed/21886577
http://dx.doi.org/10.2174/157015911795017065
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