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Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence
Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In add...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137167/ https://www.ncbi.nlm.nih.gov/pubmed/21886577 http://dx.doi.org/10.2174/157015911795017065 |
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author | Kishi, Taro Kitajima, Tsuyoshi Kawashima, Kunihiro Okochi, Tomo Yamanouchi, Yoshio Kinoshita, Yoko Ujike, Hiroshi Inada, Toshiya Yamada, Mitsuhiko Uchimura, Naohisa Sora, Ichiro Iyo, Masaomi Ozaki, Norio Iwata, Nakao |
author_facet | Kishi, Taro Kitajima, Tsuyoshi Kawashima, Kunihiro Okochi, Tomo Yamanouchi, Yoshio Kinoshita, Yoko Ujike, Hiroshi Inada, Toshiya Yamada, Mitsuhiko Uchimura, Naohisa Sora, Ichiro Iyo, Masaomi Ozaki, Norio Iwata, Nakao |
author_sort | Kishi, Taro |
collection | PubMed |
description | Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between NR1D1 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with three tagging SNPs selected by HapMap database. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between NR1D1 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population. |
format | Online Article Text |
id | pubmed-3137167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Bentham Science Publishers Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-31371672011-09-01 Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence Kishi, Taro Kitajima, Tsuyoshi Kawashima, Kunihiro Okochi, Tomo Yamanouchi, Yoshio Kinoshita, Yoko Ujike, Hiroshi Inada, Toshiya Yamada, Mitsuhiko Uchimura, Naohisa Sora, Ichiro Iyo, Masaomi Ozaki, Norio Iwata, Nakao Curr Neuropharmacol Article Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between NR1D1 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with three tagging SNPs selected by HapMap database. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between NR1D1 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population. Bentham Science Publishers Ltd 2011-03 /pmc/articles/PMC3137167/ /pubmed/21886577 http://dx.doi.org/10.2174/157015911795017065 Text en ©2011 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Kishi, Taro Kitajima, Tsuyoshi Kawashima, Kunihiro Okochi, Tomo Yamanouchi, Yoshio Kinoshita, Yoko Ujike, Hiroshi Inada, Toshiya Yamada, Mitsuhiko Uchimura, Naohisa Sora, Ichiro Iyo, Masaomi Ozaki, Norio Iwata, Nakao Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence |
title | Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence |
title_full | Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence |
title_fullStr | Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence |
title_full_unstemmed | Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence |
title_short | Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence |
title_sort | association analysis of nuclear receptor rev-erb alpha gene (nr1d1) and japanese methamphetamine dependence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137167/ https://www.ncbi.nlm.nih.gov/pubmed/21886577 http://dx.doi.org/10.2174/157015911795017065 |
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