Cargando…

Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor an...

Descripción completa

Detalles Bibliográficos
Autores principales: Okumura, Takenori, Okochi, Tomo, Kishi, Taro, Ikeda, Masashi, Kitajima, Tsuyoshi, Kinoshita, Yoko, Kawashima, Kunihiro, Tsunoka, Tomoko, Fukuo, Yasuhisa, Inada, Toshiya, Yamada, Mitsuhiko, Uchimura, Naohisa, Iyo, Masaomi, Sora, Ichiro, Ozaki, Norio, Ujike, Hiroshi, Iwata, Nakao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137172/
https://www.ncbi.nlm.nih.gov/pubmed/21886582
http://dx.doi.org/10.2174/157015911795017308
_version_ 1782208265857269760
author Okumura, Takenori
Okochi, Tomo
Kishi, Taro
Ikeda, Masashi
Kitajima, Tsuyoshi
Kinoshita, Yoko
Kawashima, Kunihiro
Tsunoka, Tomoko
Fukuo, Yasuhisa
Inada, Toshiya
Yamada, Mitsuhiko
Uchimura, Naohisa
Iyo, Masaomi
Sora, Ichiro
Ozaki, Norio
Ujike, Hiroshi
Iwata, Nakao
author_facet Okumura, Takenori
Okochi, Tomo
Kishi, Taro
Ikeda, Masashi
Kitajima, Tsuyoshi
Kinoshita, Yoko
Kawashima, Kunihiro
Tsunoka, Tomoko
Fukuo, Yasuhisa
Inada, Toshiya
Yamada, Mitsuhiko
Uchimura, Naohisa
Iyo, Masaomi
Sora, Ichiro
Ozaki, Norio
Ujike, Hiroshi
Iwata, Nakao
author_sort Okumura, Takenori
collection PubMed
description The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population.
format Online
Article
Text
id pubmed-3137172
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Bentham Science Publishers Ltd
record_format MEDLINE/PubMed
spelling pubmed-31371722011-09-01 Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese Okumura, Takenori Okochi, Tomo Kishi, Taro Ikeda, Masashi Kitajima, Tsuyoshi Kinoshita, Yoko Kawashima, Kunihiro Tsunoka, Tomoko Fukuo, Yasuhisa Inada, Toshiya Yamada, Mitsuhiko Uchimura, Naohisa Iyo, Masaomi Sora, Ichiro Ozaki, Norio Ujike, Hiroshi Iwata, Nakao Curr Neuropharmacol Article The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population. Bentham Science Publishers Ltd 2011-03 /pmc/articles/PMC3137172/ /pubmed/21886582 http://dx.doi.org/10.2174/157015911795017308 Text en ©2011 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Okumura, Takenori
Okochi, Tomo
Kishi, Taro
Ikeda, Masashi
Kitajima, Tsuyoshi
Kinoshita, Yoko
Kawashima, Kunihiro
Tsunoka, Tomoko
Fukuo, Yasuhisa
Inada, Toshiya
Yamada, Mitsuhiko
Uchimura, Naohisa
Iyo, Masaomi
Sora, Ichiro
Ozaki, Norio
Ujike, Hiroshi
Iwata, Nakao
Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese
title Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese
title_full Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese
title_fullStr Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese
title_full_unstemmed Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese
title_short Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese
title_sort genetic association analysis of nos1 and methamphetamine-induced psychosis among japanese
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137172/
https://www.ncbi.nlm.nih.gov/pubmed/21886582
http://dx.doi.org/10.2174/157015911795017308
work_keys_str_mv AT okumuratakenori geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT okochitomo geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT kishitaro geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT ikedamasashi geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT kitajimatsuyoshi geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT kinoshitayoko geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT kawashimakunihiro geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT tsunokatomoko geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT fukuoyasuhisa geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT inadatoshiya geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT yamadamitsuhiko geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT uchimuranaohisa geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT iyomasaomi geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT soraichiro geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT ozakinorio geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT ujikehiroshi geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese
AT iwatanakao geneticassociationanalysisofnos1andmethamphetamineinducedpsychosisamongjapanese