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Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders

Autism spectrum disorders (ASDs) are heterogenous neurodevelopmental disorders characterized by impairment in social, communication skills and stereotype behaviors. While autism may be uniquely human, there are behavioral characteristics in ASDs that can be mimicked using animal models. We used the...

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Autores principales: Onaivi, E.S, Benno, R, Halpern, T, Mehanovic, M, Schanz, N, Sanders, C, Yan, X, Ishiguro, H, Liu, Q-R, Berzal, A.L, Viveros, M.P, Ali, S.F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137184/
https://www.ncbi.nlm.nih.gov/pubmed/21886592
http://dx.doi.org/10.2174/157015911795017047
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author Onaivi, E.S
Benno, R
Halpern, T
Mehanovic, M
Schanz, N
Sanders, C
Yan, X
Ishiguro, H
Liu, Q-R
Berzal, A.L
Viveros, M.P
Ali, S.F
author_facet Onaivi, E.S
Benno, R
Halpern, T
Mehanovic, M
Schanz, N
Sanders, C
Yan, X
Ishiguro, H
Liu, Q-R
Berzal, A.L
Viveros, M.P
Ali, S.F
author_sort Onaivi, E.S
collection PubMed
description Autism spectrum disorders (ASDs) are heterogenous neurodevelopmental disorders characterized by impairment in social, communication skills and stereotype behaviors. While autism may be uniquely human, there are behavioral characteristics in ASDs that can be mimicked using animal models. We used the BTBR T+tf/J mice that have been shown to exhibit autism-like behavioral phenotypes to 1). Evaluate cannabinoid-induced behavioral changes using forced swim test (FST) and spontaneous wheel running (SWR) activity and 2). Determine the behavioral and neurochemical changes after the administration of MDMA (20 mg/kg), methamphetamine (10 mg/kg) or MPTP (20 mg/kg). We found that the BTBR mice exhibited an enhanced basal spontaneous locomotor behavior in the SWR test and a reduced depressogenic profile. These responses appeared to be enhanced by the prototypic cannabinoid, Δ(9)-THC. MDMA and MPTP at the doses used did not modify SWR behavior in the BTBR mice whereas MPTP reduced SWR activity in the control CB57BL/6J mice. In the hippocampus, striatum and frontal cortex, the levels of DA and 5-HT and their metabolites were differentially altered in the BTBR and C57BL/6J mice. Our data provides a basis for further studies in evaluating the role of the cannabinoid and monoaminergic systems in the etiology of ASDs.
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spelling pubmed-31371842011-09-01 Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders Onaivi, E.S Benno, R Halpern, T Mehanovic, M Schanz, N Sanders, C Yan, X Ishiguro, H Liu, Q-R Berzal, A.L Viveros, M.P Ali, S.F Curr Neuropharmacol Article Autism spectrum disorders (ASDs) are heterogenous neurodevelopmental disorders characterized by impairment in social, communication skills and stereotype behaviors. While autism may be uniquely human, there are behavioral characteristics in ASDs that can be mimicked using animal models. We used the BTBR T+tf/J mice that have been shown to exhibit autism-like behavioral phenotypes to 1). Evaluate cannabinoid-induced behavioral changes using forced swim test (FST) and spontaneous wheel running (SWR) activity and 2). Determine the behavioral and neurochemical changes after the administration of MDMA (20 mg/kg), methamphetamine (10 mg/kg) or MPTP (20 mg/kg). We found that the BTBR mice exhibited an enhanced basal spontaneous locomotor behavior in the SWR test and a reduced depressogenic profile. These responses appeared to be enhanced by the prototypic cannabinoid, Δ(9)-THC. MDMA and MPTP at the doses used did not modify SWR behavior in the BTBR mice whereas MPTP reduced SWR activity in the control CB57BL/6J mice. In the hippocampus, striatum and frontal cortex, the levels of DA and 5-HT and their metabolites were differentially altered in the BTBR and C57BL/6J mice. Our data provides a basis for further studies in evaluating the role of the cannabinoid and monoaminergic systems in the etiology of ASDs. Bentham Science Publishers Ltd 2011-03 /pmc/articles/PMC3137184/ /pubmed/21886592 http://dx.doi.org/10.2174/157015911795017047 Text en ©2011 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Onaivi, E.S
Benno, R
Halpern, T
Mehanovic, M
Schanz, N
Sanders, C
Yan, X
Ishiguro, H
Liu, Q-R
Berzal, A.L
Viveros, M.P
Ali, S.F
Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
title Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
title_full Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
title_fullStr Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
title_full_unstemmed Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
title_short Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
title_sort consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137184/
https://www.ncbi.nlm.nih.gov/pubmed/21886592
http://dx.doi.org/10.2174/157015911795017047
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