Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice

It has been demonstrated that 5-HT(1A) receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP i...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, E.-J, Kim, J.-M, Nguyen, X.-K. T, Nguyen, T.-T. L, Lee, S. Y, Jung, J.-H, Kim, M. J, Whang, W. K, Yamada, K, Nabeshima, T, Kim, H.-C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137192/
https://www.ncbi.nlm.nih.gov/pubmed/21886599
http://dx.doi.org/10.2174/157015911795017263
Descripción
Sumario:It has been demonstrated that 5-HT(1A) receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT(1A) receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT(1A) receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT(1A) in mice.

Ejemplares similares