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Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice
MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nig...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137210/ https://www.ncbi.nlm.nih.gov/pubmed/21886570 http://dx.doi.org/10.2174/157015911795016985 |
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author | Takamatsu, Y Shiotsuki, H Kasai, S Sato, S Iwamura, T Hattori, N Ikeda, K |
author_facet | Takamatsu, Y Shiotsuki, H Kasai, S Sato, S Iwamura, T Hattori, N Ikeda, K |
author_sort | Takamatsu, Y |
collection | PubMed |
description | MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway, sparing the mesolimbic pathway. Parkinson’s disease (PD) is a neurodegenerative disorder of multifactorial origin. The pathological hallmark of PD is the degeneration of DA neurons in the nigrostriatal pathway. Mutations in the parkin gene are frequently observed in autosomal recessive parkinsonism in humans. Parkin is hypothesized to protect against neurotoxic insult, and we attempted to clarify the role of parkin in MDMA-induced hyperthermia, one of the causal factors of neuronal damage, using parkin knockout mice. Body temperature was measured rectally before and 15, 30, 45, and 60 min after intraperitoneal injection of MDMA (30 mg/kg) at an ambient temperature of 22 ± 2°C. Significantly enhanced hyper-thermia after MDMA injection was observed in heterozygous and homozygous parkin knockout mice compared with wildtype mice, suggesting that parkin plays a protective role in MDMA neurotoxicity. |
format | Online Article Text |
id | pubmed-3137210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Bentham Science Publishers Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-31372102011-09-01 Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice Takamatsu, Y Shiotsuki, H Kasai, S Sato, S Iwamura, T Hattori, N Ikeda, K Curr Neuropharmacol Article MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway, sparing the mesolimbic pathway. Parkinson’s disease (PD) is a neurodegenerative disorder of multifactorial origin. The pathological hallmark of PD is the degeneration of DA neurons in the nigrostriatal pathway. Mutations in the parkin gene are frequently observed in autosomal recessive parkinsonism in humans. Parkin is hypothesized to protect against neurotoxic insult, and we attempted to clarify the role of parkin in MDMA-induced hyperthermia, one of the causal factors of neuronal damage, using parkin knockout mice. Body temperature was measured rectally before and 15, 30, 45, and 60 min after intraperitoneal injection of MDMA (30 mg/kg) at an ambient temperature of 22 ± 2°C. Significantly enhanced hyper-thermia after MDMA injection was observed in heterozygous and homozygous parkin knockout mice compared with wildtype mice, suggesting that parkin plays a protective role in MDMA neurotoxicity. Bentham Science Publishers Ltd 2011-03 /pmc/articles/PMC3137210/ /pubmed/21886570 http://dx.doi.org/10.2174/157015911795016985 Text en ©2011 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Takamatsu, Y Shiotsuki, H Kasai, S Sato, S Iwamura, T Hattori, N Ikeda, K Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice |
title | Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice |
title_full | Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice |
title_fullStr | Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice |
title_full_unstemmed | Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice |
title_short | Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice |
title_sort | enhanced hyperthermia induced by mdma in parkin knockout mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137210/ https://www.ncbi.nlm.nih.gov/pubmed/21886570 http://dx.doi.org/10.2174/157015911795016985 |
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