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False positive peaks in ChIP-seq and other sequencing-based functional assays caused by unannotated high copy number regions
Motivation: Sequencing-based assays such as ChIP-seq, DNase-seq and MNase-seq have become important tools for genome annotation. In these assays, short sequence reads enriched for loci of interest are mapped to a reference genome to determine their origin. Here, we consider whether false positive pe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137225/ https://www.ncbi.nlm.nih.gov/pubmed/21690102 http://dx.doi.org/10.1093/bioinformatics/btr354 |