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Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats

Sleep disturbance is considered as an important symptom of acute and protracted opiate withdrawal. Current results suggest that sleep disturbance may be taken as a predictor of relapse. Appropriate sleep enhancement therapy will be in favor of the retention in treatment for opiate addicts. Our previ...

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Autores principales: Li, Yi-Jing, Zhong, Fei, Yu, Peng, Han, Ji-Sheng, Cui, Cai-Lian, Wu, Liu-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137251/
https://www.ncbi.nlm.nih.gov/pubmed/19734257
http://dx.doi.org/10.1093/ecam/nep133
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author Li, Yi-Jing
Zhong, Fei
Yu, Peng
Han, Ji-Sheng
Cui, Cai-Lian
Wu, Liu-Zhen
author_facet Li, Yi-Jing
Zhong, Fei
Yu, Peng
Han, Ji-Sheng
Cui, Cai-Lian
Wu, Liu-Zhen
author_sort Li, Yi-Jing
collection PubMed
description Sleep disturbance is considered as an important symptom of acute and protracted opiate withdrawal. Current results suggest that sleep disturbance may be taken as a predictor of relapse. Appropriate sleep enhancement therapy will be in favor of the retention in treatment for opiate addicts. Our previous studies have shown that electroacupuncture (EA) is effective in suppressing morphine withdrawal syndrome. The aim of the present study is to investigate the effect of 2 and 100 Hz EA on the sleep disturbance during morphine withdrawal. Rats were made dependent on morphine by repeated morphine injections (escalating doses of 5–80 mg kg(−1), subcutaneously, twice a day) for 5 days. EA of 2 or 100 Hz was given twice a day for 3 days, starting at 48 h after the last morphine injection. Electroencephalogram and electromyogram were monitored at the end of the first and the last EA treatments, respectively. Results showed that non-rapid eye movement (NREM) sleep, REM sleep and total sleep time decreased dramatically, while the sleep latency prolonged significantly during acute morphine withdrawal. Both 2 and 100 Hz EA produced a significant increase in NREM sleep, REM sleep and total sleep time. It was suggested that EA could be a potential treatment for sleep disturbance during morphine withdrawal.
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spelling pubmed-31372512011-07-22 Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats Li, Yi-Jing Zhong, Fei Yu, Peng Han, Ji-Sheng Cui, Cai-Lian Wu, Liu-Zhen Evid Based Complement Alternat Med Original Article Sleep disturbance is considered as an important symptom of acute and protracted opiate withdrawal. Current results suggest that sleep disturbance may be taken as a predictor of relapse. Appropriate sleep enhancement therapy will be in favor of the retention in treatment for opiate addicts. Our previous studies have shown that electroacupuncture (EA) is effective in suppressing morphine withdrawal syndrome. The aim of the present study is to investigate the effect of 2 and 100 Hz EA on the sleep disturbance during morphine withdrawal. Rats were made dependent on morphine by repeated morphine injections (escalating doses of 5–80 mg kg(−1), subcutaneously, twice a day) for 5 days. EA of 2 or 100 Hz was given twice a day for 3 days, starting at 48 h after the last morphine injection. Electroencephalogram and electromyogram were monitored at the end of the first and the last EA treatments, respectively. Results showed that non-rapid eye movement (NREM) sleep, REM sleep and total sleep time decreased dramatically, while the sleep latency prolonged significantly during acute morphine withdrawal. Both 2 and 100 Hz EA produced a significant increase in NREM sleep, REM sleep and total sleep time. It was suggested that EA could be a potential treatment for sleep disturbance during morphine withdrawal. Hindawi Publishing Corporation 2011 2011-05-26 /pmc/articles/PMC3137251/ /pubmed/19734257 http://dx.doi.org/10.1093/ecam/nep133 Text en Copyright © 2011 Yi-Jing Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Li, Yi-Jing
Zhong, Fei
Yu, Peng
Han, Ji-Sheng
Cui, Cai-Lian
Wu, Liu-Zhen
Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
title Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
title_full Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
title_fullStr Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
title_full_unstemmed Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
title_short Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
title_sort electroacupuncture treatment normalized sleep disturbance in morphine withdrawal rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137251/
https://www.ncbi.nlm.nih.gov/pubmed/19734257
http://dx.doi.org/10.1093/ecam/nep133
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