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Clinical implications of hedgehog signaling pathway inhibitors

Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and Carcinogenesis. The first link of Hh signa...

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Detalles Bibliográficos
Autores principales: Liu, Hailan, Gu, Dongsheng, Xie, Jingwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137255/
https://www.ncbi.nlm.nih.gov/pubmed/21192841
http://dx.doi.org/10.5732/cjc.010.10540
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author Liu, Hailan
Gu, Dongsheng
Xie, Jingwu
author_facet Liu, Hailan
Gu, Dongsheng
Xie, Jingwu
author_sort Liu, Hailan
collection PubMed
description Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and Carcinogenesis. The first link of Hh signaling to cancer was established through studies of a rare familial disease, Gorlin syndrome, in 1996. Follow-up studies revealed activation of this pathway in basal cell carcinoma, medulloblastoma and, leukemia as well as in gastrointestinal, lung, ovarian, breast, and prostate cancer. Targeted inhibition of Hh signaling is now believed to be effective in the treatment and prevention of human cancer. The discovery and synthesis of specific inhibitors for this pathway are even more exciting. In this review, we summarize major advances in the understanding of Hh signaling pathway activation in human cancer, mouse models for studying Hh-mediated Carcinogenesis, the roles of Hh signaling in tumor development and metastasis, antagonists for Hh signaling and their clinical implications.
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spelling pubmed-31372552011-07-15 Clinical implications of hedgehog signaling pathway inhibitors Liu, Hailan Gu, Dongsheng Xie, Jingwu Chin J Cancer Review Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and Carcinogenesis. The first link of Hh signaling to cancer was established through studies of a rare familial disease, Gorlin syndrome, in 1996. Follow-up studies revealed activation of this pathway in basal cell carcinoma, medulloblastoma and, leukemia as well as in gastrointestinal, lung, ovarian, breast, and prostate cancer. Targeted inhibition of Hh signaling is now believed to be effective in the treatment and prevention of human cancer. The discovery and synthesis of specific inhibitors for this pathway are even more exciting. In this review, we summarize major advances in the understanding of Hh signaling pathway activation in human cancer, mouse models for studying Hh-mediated Carcinogenesis, the roles of Hh signaling in tumor development and metastasis, antagonists for Hh signaling and their clinical implications. Sun Yat-sen University Cancer Center 2011-01 /pmc/articles/PMC3137255/ /pubmed/21192841 http://dx.doi.org/10.5732/cjc.010.10540 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Review
Liu, Hailan
Gu, Dongsheng
Xie, Jingwu
Clinical implications of hedgehog signaling pathway inhibitors
title Clinical implications of hedgehog signaling pathway inhibitors
title_full Clinical implications of hedgehog signaling pathway inhibitors
title_fullStr Clinical implications of hedgehog signaling pathway inhibitors
title_full_unstemmed Clinical implications of hedgehog signaling pathway inhibitors
title_short Clinical implications of hedgehog signaling pathway inhibitors
title_sort clinical implications of hedgehog signaling pathway inhibitors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137255/
https://www.ncbi.nlm.nih.gov/pubmed/21192841
http://dx.doi.org/10.5732/cjc.010.10540
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