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Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study
OBJECTIVES: The objective of this pilot study was to evaluate the effects of three different antiseptic materials on healing processes of direct pulp therapies with Ca(OH)(2) histopathologically. METHODS: Twenty-eight upper and lower first molar teeth from 7 male Wistar rats were used in this study....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dental Investigations Society
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137439/ https://www.ncbi.nlm.nih.gov/pubmed/21769267 |
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author | Bal, Cenkhan Alacam, Alev Tuzuner, Tamer Tirali, Resmiye Ebru Baris, Emre |
author_facet | Bal, Cenkhan Alacam, Alev Tuzuner, Tamer Tirali, Resmiye Ebru Baris, Emre |
author_sort | Bal, Cenkhan |
collection | PubMed |
description | OBJECTIVES: The objective of this pilot study was to evaluate the effects of three different antiseptic materials on healing processes of direct pulp therapies with Ca(OH)(2) histopathologically. METHODS: Twenty-eight upper and lower first molar teeth from 7 male Wistar rats were used in this study. Four cavities were prepared in each rat in four quadrants, and each quadrant represented different experimental groups. In Group I: 0.5% sodium hypochlorite (NaOCl); in Group II: 2% chlorhexidine digluconate (CHX); in Group III: 0.1% octenidine dihydrochloride (OCT); and in Group IV 0.9% sterile saline was applied to the exposure site with a sterile cotton pellet for 3 minutes. After hemorrhage control, the pulps were capped with hard setting Ca(OH)(2) and, finally, restored with IRM. The animals were euthanized at 21 days post-operatively. After sacrificing, routine histological procedures were performed and evaluated statistically with non-parametric Kruskal-Wallis test among the groups and two-by-two comparisons by using the Mann-Whitney U test for inflammatory response and tissue organization scores at the confidence interval of 95%. RESULTS: There were significant differences in inflammatory response and tissue organization scores between the groups (P<.05). Statistical evaluation of inflammatory response showed that Group IV was significantly different from Groups I, II and III separately with a higher inflammatory cell response (P<.05) whereas no significant differences were detected between the other groups in two-by-two comparisons (P>.05). Healthy coronal and radicular pulp tissue organization scores indicated that the Group I has better pulp tissue organization than Group IV and this was significantly different (P<.05) whereas no significant differences were observed between the other groups separately (P>.05). CONCLUSIONS: The antiseptic materials used in this study created an environment that, rather than saline solution, may affect clinical and histological success in a positive way. |
format | Online Article Text |
id | pubmed-3137439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dental Investigations Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-31374392011-07-18 Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study Bal, Cenkhan Alacam, Alev Tuzuner, Tamer Tirali, Resmiye Ebru Baris, Emre Eur J Dent Original Articles OBJECTIVES: The objective of this pilot study was to evaluate the effects of three different antiseptic materials on healing processes of direct pulp therapies with Ca(OH)(2) histopathologically. METHODS: Twenty-eight upper and lower first molar teeth from 7 male Wistar rats were used in this study. Four cavities were prepared in each rat in four quadrants, and each quadrant represented different experimental groups. In Group I: 0.5% sodium hypochlorite (NaOCl); in Group II: 2% chlorhexidine digluconate (CHX); in Group III: 0.1% octenidine dihydrochloride (OCT); and in Group IV 0.9% sterile saline was applied to the exposure site with a sterile cotton pellet for 3 minutes. After hemorrhage control, the pulps were capped with hard setting Ca(OH)(2) and, finally, restored with IRM. The animals were euthanized at 21 days post-operatively. After sacrificing, routine histological procedures were performed and evaluated statistically with non-parametric Kruskal-Wallis test among the groups and two-by-two comparisons by using the Mann-Whitney U test for inflammatory response and tissue organization scores at the confidence interval of 95%. RESULTS: There were significant differences in inflammatory response and tissue organization scores between the groups (P<.05). Statistical evaluation of inflammatory response showed that Group IV was significantly different from Groups I, II and III separately with a higher inflammatory cell response (P<.05) whereas no significant differences were detected between the other groups in two-by-two comparisons (P>.05). Healthy coronal and radicular pulp tissue organization scores indicated that the Group I has better pulp tissue organization than Group IV and this was significantly different (P<.05) whereas no significant differences were observed between the other groups separately (P>.05). CONCLUSIONS: The antiseptic materials used in this study created an environment that, rather than saline solution, may affect clinical and histological success in a positive way. Dental Investigations Society 2011-07 /pmc/articles/PMC3137439/ /pubmed/21769267 Text en Copyright 2011 European Journal of Dentistry. All rights reserved. |
spellingShingle | Original Articles Bal, Cenkhan Alacam, Alev Tuzuner, Tamer Tirali, Resmiye Ebru Baris, Emre Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study |
title | Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study |
title_full | Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study |
title_fullStr | Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study |
title_full_unstemmed | Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study |
title_short | Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study |
title_sort | effects of antiseptics on pulpal healing under calcium hydroxide pulp capping: a pilot study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137439/ https://www.ncbi.nlm.nih.gov/pubmed/21769267 |
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