Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols

PURPOSE: Bisretinoids such as A2E that accumulate as components of the lipofuscin of retinal pigment epithelial cells are implicated in some retinal disease processes. These compounds undergo light-induced oxidation and cleavage with the latter releasing of a mixture of aldehyde-bearing fragments, i...

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Detalles Bibliográficos
Autores principales: Yoon, Kee Dong, Yamamoto, Kazunori, Zhou, Jilin, Sparrow, Janet R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137558/
https://www.ncbi.nlm.nih.gov/pubmed/21850158

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