Cargando…

Ensemble Place Codes in Hippocampus: CA1, CA3, and Dentate Gyrus Place Cells Have Multiple Place Fields in Large Environments

Previously we reported that the hippocampus place code must be an ensemble code because place cells in the CA1 region of hippocampus have multiple place fields in a more natural, larger-than-standard enclosure with stairs that permitted movements in 3-D. Here, we further investigated the nature of h...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, EunHye, Dvorak, Dino, Fenton, André A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137630/
https://www.ncbi.nlm.nih.gov/pubmed/21789250
http://dx.doi.org/10.1371/journal.pone.0022349
_version_ 1782208307480494080
author Park, EunHye
Dvorak, Dino
Fenton, André A.
author_facet Park, EunHye
Dvorak, Dino
Fenton, André A.
author_sort Park, EunHye
collection PubMed
description Previously we reported that the hippocampus place code must be an ensemble code because place cells in the CA1 region of hippocampus have multiple place fields in a more natural, larger-than-standard enclosure with stairs that permitted movements in 3-D. Here, we further investigated the nature of hippocampal place codes by characterizing the spatial firing properties of place cells in the CA1, CA3, and dentate gyrus (DG) hippocampal subdivisions as rats foraged in a standard 76-cm cylinder as well as a larger-than-standard box (1.8 m×1.4 m) that did not have stairs or any internal structure to permit movements in 3-D. The rats were trained to forage continuously for 1 hour using computer-controlled food delivery. We confirmed that most place cells have single place fields in the standard cylinder and that the positional firing pattern remapped between the cylinder and the large enclosure. Importantly, place cells in the CA1, CA3 and DG areas all characteristically had multiple place fields that were irregularly spaced, as we had reported previously for CA1. We conclude that multiple place fields are a fundamental characteristic of hippocampal place cells that simplifies to a single field in sufficiently small spaces. An ensemble place code is compatible with these observations, which contradict any dedicated coding scheme.
format Online
Article
Text
id pubmed-3137630
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-31376302011-07-25 Ensemble Place Codes in Hippocampus: CA1, CA3, and Dentate Gyrus Place Cells Have Multiple Place Fields in Large Environments Park, EunHye Dvorak, Dino Fenton, André A. PLoS One Research Article Previously we reported that the hippocampus place code must be an ensemble code because place cells in the CA1 region of hippocampus have multiple place fields in a more natural, larger-than-standard enclosure with stairs that permitted movements in 3-D. Here, we further investigated the nature of hippocampal place codes by characterizing the spatial firing properties of place cells in the CA1, CA3, and dentate gyrus (DG) hippocampal subdivisions as rats foraged in a standard 76-cm cylinder as well as a larger-than-standard box (1.8 m×1.4 m) that did not have stairs or any internal structure to permit movements in 3-D. The rats were trained to forage continuously for 1 hour using computer-controlled food delivery. We confirmed that most place cells have single place fields in the standard cylinder and that the positional firing pattern remapped between the cylinder and the large enclosure. Importantly, place cells in the CA1, CA3 and DG areas all characteristically had multiple place fields that were irregularly spaced, as we had reported previously for CA1. We conclude that multiple place fields are a fundamental characteristic of hippocampal place cells that simplifies to a single field in sufficiently small spaces. An ensemble place code is compatible with these observations, which contradict any dedicated coding scheme. Public Library of Science 2011-07-15 /pmc/articles/PMC3137630/ /pubmed/21789250 http://dx.doi.org/10.1371/journal.pone.0022349 Text en Park et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Park, EunHye
Dvorak, Dino
Fenton, André A.
Ensemble Place Codes in Hippocampus: CA1, CA3, and Dentate Gyrus Place Cells Have Multiple Place Fields in Large Environments
title Ensemble Place Codes in Hippocampus: CA1, CA3, and Dentate Gyrus Place Cells Have Multiple Place Fields in Large Environments
title_full Ensemble Place Codes in Hippocampus: CA1, CA3, and Dentate Gyrus Place Cells Have Multiple Place Fields in Large Environments
title_fullStr Ensemble Place Codes in Hippocampus: CA1, CA3, and Dentate Gyrus Place Cells Have Multiple Place Fields in Large Environments
title_full_unstemmed Ensemble Place Codes in Hippocampus: CA1, CA3, and Dentate Gyrus Place Cells Have Multiple Place Fields in Large Environments
title_short Ensemble Place Codes in Hippocampus: CA1, CA3, and Dentate Gyrus Place Cells Have Multiple Place Fields in Large Environments
title_sort ensemble place codes in hippocampus: ca1, ca3, and dentate gyrus place cells have multiple place fields in large environments
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137630/
https://www.ncbi.nlm.nih.gov/pubmed/21789250
http://dx.doi.org/10.1371/journal.pone.0022349
work_keys_str_mv AT parkeunhye ensembleplacecodesinhippocampusca1ca3anddentategyrusplacecellshavemultipleplacefieldsinlargeenvironments
AT dvorakdino ensembleplacecodesinhippocampusca1ca3anddentategyrusplacecellshavemultipleplacefieldsinlargeenvironments
AT fentonandrea ensembleplacecodesinhippocampusca1ca3anddentategyrusplacecellshavemultipleplacefieldsinlargeenvironments