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Dibucaine Mitigates Spreading Depolarization in Human Neocortical Slices and Prevents Acute Dendritic Injury in the Ischemic Rodent Neocortex
BACKGROUND: Spreading depolarizations that occur in patients with malignant stroke, subarachnoid/intracranial hemorrhage, and traumatic brain injury are known to facilitate neuronal damage in metabolically compromised brain tissue. The dramatic failure of brain ion homeostasis caused by propagating...
Autores principales: | Risher, W. Christopher, Lee, Mark R., Fomitcheva, Ioulia V., Hess, David C., Kirov, Sergei A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137632/ https://www.ncbi.nlm.nih.gov/pubmed/21789251 http://dx.doi.org/10.1371/journal.pone.0022351 |
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