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Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice

Radix Pseudostellariae is used as a tonic drug in traditional Chinese medicine with immunomodulating and anti-fatigue activities, and the polysaccharide is considered as the main active component. The purpose of this study is to examine the effect of the polysaccharide isolated from Radix Pseudostel...

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Autores principales: Sheng, Rong, Xu, Xianxiang, Tang, Qin, Bian, Difei, Li, Ying, Qian, Cheng, He, Xin, Gao, Xinghua, Pan, Rong, Wang, Chong, Luo, Yubin, Xia, Yufeng, Dai, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137695/
https://www.ncbi.nlm.nih.gov/pubmed/20008077
http://dx.doi.org/10.1093/ecam/nep208
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author Sheng, Rong
Xu, Xianxiang
Tang, Qin
Bian, Difei
Li, Ying
Qian, Cheng
He, Xin
Gao, Xinghua
Pan, Rong
Wang, Chong
Luo, Yubin
Xia, Yufeng
Dai, Yue
author_facet Sheng, Rong
Xu, Xianxiang
Tang, Qin
Bian, Difei
Li, Ying
Qian, Cheng
He, Xin
Gao, Xinghua
Pan, Rong
Wang, Chong
Luo, Yubin
Xia, Yufeng
Dai, Yue
author_sort Sheng, Rong
collection PubMed
description Radix Pseudostellariae is used as a tonic drug in traditional Chinese medicine with immunomodulating and anti-fatigue activities, and the polysaccharide is considered as the main active component. The purpose of this study is to examine the effect of the polysaccharide isolated from Radix Pseudostellariae (PRP) on mouse chronic fatigue syndrome (CFS) induced by intraperitoneal injection of polyriboinosinic:polyribocytidylic acid (poly I:C), a double-stranded synthetic RNA. It has shown that the fatigue symptom of mice lasted at least 1 week as evaluated by forced swimming time. PRP (100, 200, 400 mg kg(−1)), orally administered 3 days before poly I:C injection, showed dose-dependent anti-fatigue effects. In addition, poly I:C led to evident alternations in neuroendocrine and immune systems of mice, such as reduced spontaneous activity and learning ability, declined serum level of corticosterone, increased weight indexes and T lymphocyte numbers in thymuses and spleens, and increased CD4(+)/CD8(+) ratio but decreased proliferation ability of T lymphocytes in spleens. PRP alleviated the abnormalities caused by poly I:C, and restored the function of hosts to normal conditions. The findings suggest that PRP is beneficial to CFS, and the underlying mechanisms of action involve neuroendocrine and immune systems.
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spelling pubmed-31376952011-07-26 Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice Sheng, Rong Xu, Xianxiang Tang, Qin Bian, Difei Li, Ying Qian, Cheng He, Xin Gao, Xinghua Pan, Rong Wang, Chong Luo, Yubin Xia, Yufeng Dai, Yue Evid Based Complement Alternat Med Original Article Radix Pseudostellariae is used as a tonic drug in traditional Chinese medicine with immunomodulating and anti-fatigue activities, and the polysaccharide is considered as the main active component. The purpose of this study is to examine the effect of the polysaccharide isolated from Radix Pseudostellariae (PRP) on mouse chronic fatigue syndrome (CFS) induced by intraperitoneal injection of polyriboinosinic:polyribocytidylic acid (poly I:C), a double-stranded synthetic RNA. It has shown that the fatigue symptom of mice lasted at least 1 week as evaluated by forced swimming time. PRP (100, 200, 400 mg kg(−1)), orally administered 3 days before poly I:C injection, showed dose-dependent anti-fatigue effects. In addition, poly I:C led to evident alternations in neuroendocrine and immune systems of mice, such as reduced spontaneous activity and learning ability, declined serum level of corticosterone, increased weight indexes and T lymphocyte numbers in thymuses and spleens, and increased CD4(+)/CD8(+) ratio but decreased proliferation ability of T lymphocytes in spleens. PRP alleviated the abnormalities caused by poly I:C, and restored the function of hosts to normal conditions. The findings suggest that PRP is beneficial to CFS, and the underlying mechanisms of action involve neuroendocrine and immune systems. Hindawi Publishing Corporation 2011 2011-06-23 /pmc/articles/PMC3137695/ /pubmed/20008077 http://dx.doi.org/10.1093/ecam/nep208 Text en Copyright © 2011 Rong Sheng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sheng, Rong
Xu, Xianxiang
Tang, Qin
Bian, Difei
Li, Ying
Qian, Cheng
He, Xin
Gao, Xinghua
Pan, Rong
Wang, Chong
Luo, Yubin
Xia, Yufeng
Dai, Yue
Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice
title Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice
title_full Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice
title_fullStr Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice
title_full_unstemmed Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice
title_short Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice
title_sort polysaccharide of radix pseudostellariae improves chronic fatigue syndrome induced by poly i:c in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137695/
https://www.ncbi.nlm.nih.gov/pubmed/20008077
http://dx.doi.org/10.1093/ecam/nep208
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