New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes

Orthotropic liver transplantation is the only established treatment for end-stage liver diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as alternative therapeutic approaches requires an unlimited source of hepatocytes. Stem cells, especially embryonic stem cells,...

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Autores principales: Behbahan, Iman Saramipoor, Duan, Yuyou, Lam, Alexander, Khoobyari, Shiva, Ma, Xiaocui, Ahuja, Tijess P., Zern, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137783/
https://www.ncbi.nlm.nih.gov/pubmed/21336836
http://dx.doi.org/10.1007/s12015-010-9216-4
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author Behbahan, Iman Saramipoor
Duan, Yuyou
Lam, Alexander
Khoobyari, Shiva
Ma, Xiaocui
Ahuja, Tijess P.
Zern, Mark A.
author_facet Behbahan, Iman Saramipoor
Duan, Yuyou
Lam, Alexander
Khoobyari, Shiva
Ma, Xiaocui
Ahuja, Tijess P.
Zern, Mark A.
author_sort Behbahan, Iman Saramipoor
collection PubMed
description Orthotropic liver transplantation is the only established treatment for end-stage liver diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as alternative therapeutic approaches requires an unlimited source of hepatocytes. Stem cells, especially embryonic stem cells, possessing the ability to produce functional hepatocytes for clinical applications and drug development, may provide the answer to this problem. New discoveries in the mechanisms of liver development and the emergence of induced pluripotent stem cells in 2006 have provided novel insights into hepatocyte differentiation and the use of stem cells for therapeutic applications. This review is aimed towards providing scientists and physicians with the latest advancements in this rapidly progressing field.
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spelling pubmed-31377832011-08-26 New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes Behbahan, Iman Saramipoor Duan, Yuyou Lam, Alexander Khoobyari, Shiva Ma, Xiaocui Ahuja, Tijess P. Zern, Mark A. Stem Cell Rev Article Orthotropic liver transplantation is the only established treatment for end-stage liver diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as alternative therapeutic approaches requires an unlimited source of hepatocytes. Stem cells, especially embryonic stem cells, possessing the ability to produce functional hepatocytes for clinical applications and drug development, may provide the answer to this problem. New discoveries in the mechanisms of liver development and the emergence of induced pluripotent stem cells in 2006 have provided novel insights into hepatocyte differentiation and the use of stem cells for therapeutic applications. This review is aimed towards providing scientists and physicians with the latest advancements in this rapidly progressing field. Humana Press Inc 2011-02-19 2011 /pmc/articles/PMC3137783/ /pubmed/21336836 http://dx.doi.org/10.1007/s12015-010-9216-4 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Behbahan, Iman Saramipoor
Duan, Yuyou
Lam, Alexander
Khoobyari, Shiva
Ma, Xiaocui
Ahuja, Tijess P.
Zern, Mark A.
New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes
title New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes
title_full New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes
title_fullStr New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes
title_full_unstemmed New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes
title_short New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes
title_sort new approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137783/
https://www.ncbi.nlm.nih.gov/pubmed/21336836
http://dx.doi.org/10.1007/s12015-010-9216-4
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