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An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder

OBJECTIVE: Various studies have shown the effectiveness of risperidone and fluoxetine in the management of behavioral problems in autism. AIM: The purpose of this study was to compare these two drugs in the management of behavioral problems in autism. MATERIALS AND METHODS: Forty children with autis...

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Autor principal: Desousa, Avinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137806/
https://www.ncbi.nlm.nih.gov/pubmed/21799554
http://dx.doi.org/10.4103/0253-7176.70522
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author Desousa, Avinash
author_facet Desousa, Avinash
author_sort Desousa, Avinash
collection PubMed
description OBJECTIVE: Various studies have shown the effectiveness of risperidone and fluoxetine in the management of behavioral problems in autism. AIM: The purpose of this study was to compare these two drugs in the management of behavioral problems in autism. MATERIALS AND METHODS: Forty children with autism were divided into 2 groups in a 16-week open trial that compared these two drugs. Parents rated the children using the Aberrant Behavior Checklist (ABC) and the Conners′ Parent Rating Scale – Revised (CPRS-R). The author rated the children using the Children's Psychiatric Rating Scale and Clinical Global Impression (CGI) Scale. RESULTS: The risperidone group showed significant improvement in areas like irritability and hyperactivity, while the fluoxetine group showed significant improvement in speech deviance, social withdrawal and stereotypy. When the two drugs were compared, fluoxetine showed greater improvement in stereotypy, while both drugs showed improvement on the general autism scale; and on anger, hyperactivity and irritability scales. CONCLUSIONS: In this open trial, both drugs were well tolerated and appeared to be beneficial in the treatment of common behavioral problems in children with autism. Further controlled and double-blind studies in larger samples are warranted.
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spelling pubmed-31378062011-07-28 An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder Desousa, Avinash Indian J Psychol Med Original Article OBJECTIVE: Various studies have shown the effectiveness of risperidone and fluoxetine in the management of behavioral problems in autism. AIM: The purpose of this study was to compare these two drugs in the management of behavioral problems in autism. MATERIALS AND METHODS: Forty children with autism were divided into 2 groups in a 16-week open trial that compared these two drugs. Parents rated the children using the Aberrant Behavior Checklist (ABC) and the Conners′ Parent Rating Scale – Revised (CPRS-R). The author rated the children using the Children's Psychiatric Rating Scale and Clinical Global Impression (CGI) Scale. RESULTS: The risperidone group showed significant improvement in areas like irritability and hyperactivity, while the fluoxetine group showed significant improvement in speech deviance, social withdrawal and stereotypy. When the two drugs were compared, fluoxetine showed greater improvement in stereotypy, while both drugs showed improvement on the general autism scale; and on anger, hyperactivity and irritability scales. CONCLUSIONS: In this open trial, both drugs were well tolerated and appeared to be beneficial in the treatment of common behavioral problems in children with autism. Further controlled and double-blind studies in larger samples are warranted. Medknow Publications 2010 /pmc/articles/PMC3137806/ /pubmed/21799554 http://dx.doi.org/10.4103/0253-7176.70522 Text en © Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Desousa, Avinash
An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder
title An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder
title_full An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder
title_fullStr An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder
title_full_unstemmed An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder
title_short An Open-label Trial of Risperidone and Fluoxetine in Children with Autistic Disorder
title_sort open-label trial of risperidone and fluoxetine in children with autistic disorder
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137806/
https://www.ncbi.nlm.nih.gov/pubmed/21799554
http://dx.doi.org/10.4103/0253-7176.70522
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