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Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma

New developments in the field of thoracic oncology have challenged the way pathologists approach the diagnosis of pulmonary carcinoma. Nonsmall cell carcinoma is no longer an adequate diagnostic category. Pathologists are required to further classify tumors into adenocarcinoma and squamous cell carc...

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Autores principales: Hasanovic, Adnan, Rekhtman, Natasha, Sigel, Carlie S., Moreira, Andre L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137976/
https://www.ncbi.nlm.nih.gov/pubmed/21776344
http://dx.doi.org/10.4061/2011/897292
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author Hasanovic, Adnan
Rekhtman, Natasha
Sigel, Carlie S.
Moreira, Andre L.
author_facet Hasanovic, Adnan
Rekhtman, Natasha
Sigel, Carlie S.
Moreira, Andre L.
author_sort Hasanovic, Adnan
collection PubMed
description New developments in the field of thoracic oncology have challenged the way pathologists approach the diagnosis of pulmonary carcinoma. Nonsmall cell carcinoma is no longer an adequate diagnostic category. Pathologists are required to further classify tumors into adenocarcinoma and squamous cell carcinoma since specific therapies are now recommended depending on the histological tumor type. This change occurred following the discovery of specific molecular alterations that predict response to certain drugs and now molecular testing of tumor cells is often requested to direct therapy. The vast majority of lung cancer is diagnosed in advanced clinical stages, where cytologic or small biopsy material is the only form of tissue diagnosis, thus placing cytology, especially fine needle aspiration biopsy in the front line for management of patients with lung cancer. In this paper we will review the current concepts in the suitability and accuracy of fine needle aspiration biopsy, including diagnosis, classification, prognostic markers, and use of ancillary techniques.
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spelling pubmed-31379762011-07-20 Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma Hasanovic, Adnan Rekhtman, Natasha Sigel, Carlie S. Moreira, Andre L. Patholog Res Int Review Article New developments in the field of thoracic oncology have challenged the way pathologists approach the diagnosis of pulmonary carcinoma. Nonsmall cell carcinoma is no longer an adequate diagnostic category. Pathologists are required to further classify tumors into adenocarcinoma and squamous cell carcinoma since specific therapies are now recommended depending on the histological tumor type. This change occurred following the discovery of specific molecular alterations that predict response to certain drugs and now molecular testing of tumor cells is often requested to direct therapy. The vast majority of lung cancer is diagnosed in advanced clinical stages, where cytologic or small biopsy material is the only form of tissue diagnosis, thus placing cytology, especially fine needle aspiration biopsy in the front line for management of patients with lung cancer. In this paper we will review the current concepts in the suitability and accuracy of fine needle aspiration biopsy, including diagnosis, classification, prognostic markers, and use of ancillary techniques. SAGE-Hindawi Access to Research 2011-06-27 /pmc/articles/PMC3137976/ /pubmed/21776344 http://dx.doi.org/10.4061/2011/897292 Text en Copyright © 2011 Adnan Hasanovic et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hasanovic, Adnan
Rekhtman, Natasha
Sigel, Carlie S.
Moreira, Andre L.
Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma
title Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma
title_full Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma
title_fullStr Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma
title_full_unstemmed Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma
title_short Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma
title_sort advances in fine needle aspiration cytology for the diagnosis of pulmonary carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137976/
https://www.ncbi.nlm.nih.gov/pubmed/21776344
http://dx.doi.org/10.4061/2011/897292
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