Cargando…

Glucose Regulates Free Cytosolic Zn(2+) Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet β-Cells

Zn(2+) is an important cofactor for insulin biosynthesis and storage in pancreatic β-cells. Correspondingly, polymorphisms in the SLC30A8 gene, encoding the secretory granule Zn(2+) transporter ZnT8, are associated with type 2 diabetes risk. Using a genetically engineered (FRET)-based sensor (eCALWY...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bellomo, Elisa A., Meur, Gargi, Rutter, Guy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138249/ https://www.ncbi.nlm.nih.gov/pubmed/21613223 http://dx.doi.org/10.1074/jbc.M111.246082

Ejemplares similares

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells
por: Gerber, Philipp A., et al.
Publicado: (2014)

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance
por: Mitchell, Ryan K., et al.
Publicado: (2016)

The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective
por: Kimura, Tomoki, et al.
Publicado: (2016)

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion
por: Solomou, Antonia, et al.
Publicado: (2015)

Long Noncoding RNA, MicroRNA, Zn Transporter Zip14 (Slc39a14) and Inflammation in Mice
por: Jimenez-Rondan, Felix R., et al.
Publicado: (2022)

Recent Advances in the Role of SLC39A/ZIP Zinc Transporters In Vivo
por: Takagishi, Teruhisa, et al.
Publicado: (2017)

Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice
por: HIROSE, Takuya, et al.
Publicado: (2018)

Overproduction of Human Zip (SLC39) Zinc Transporters in Saccharomyces cerevisiae for Biophysical Characterization
por: Becares, Eva Ramos, et al.
Publicado: (2021)

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells
por: Noordeen, Nafeesa A., et al.
Publicado: (2012)

ZIP7 (SLC39A7) expression in colorectal cancer and its correlation with clinical prognosis
por: Luo, Yang, et al.
Publicado: (2020)

Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION
por: Liu, Ying, et al.
Publicado: (2015)

Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish
por: Yan, Guang, et al.
Publicado: (2012)

The Zinc Transporter, Slc39a7 (Zip7) Is Implicated in Glycaemic Control in Skeletal Muscle Cells
por: Myers, Stephen A., et al.
Publicado: (2013)

Expression of the ZIP/SLC39A transporters in β-cells: a systematic review and integration of multiple datasets
por: Lawson, Rebecca, et al.
Publicado: (2017)

Cytosolic Distribution of Cd(2+), Cu(2+), and Zn(2+) Among Metallothionein-Like Proteins in Lobster Hepatopancreas
por: Schultz, Joseph, et al.
Publicado: (1994)

MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis
por: Song, Jinsoo, et al.
Publicado: (2013)

The zinc transporter ZIP9 (Slc39a9) regulates zinc dynamics essential to egg activation in zebrafish
por: Converse, Aubrey, et al.
Publicado: (2020)

Islet cilia and glucose homeostasis
por: Melena, Isabella, et al.
Publicado: (2022)

Regulation of zinc-responsive Slc39a5 (Zip5) translation is mediated by conserved elements in the 3′-untranslated region
por: Weaver, Benjamin P., et al.
Publicado: (2011)

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress
por: Ohashi, Wakana, et al.
Publicado: (2016)

Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis
por: Hendrickx, Gretl, et al.
Publicado: (2018)

Metal Transporter SLC39A14/ZIP14-Mediated Zinc Transport Modulates the Gut Microbiome and Host Metabolism
por: Aydemir, Tolunay Beker, et al.
Publicado: (2022)

The Zinc Transporter Zip5 (Slc39a5) Regulates Intestinal Zinc Excretion and Protects the Pancreas against Zinc Toxicity
por: Geiser, Jim, et al.
Publicado: (2013)

Comparative study of dermal components and plasma TGF-β1 levels in Slc39a13/Zip13-KO mice
por: HIROSE, Takuya, et al.
Publicado: (2015)

Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2)
por: Gyimesi, Gergely, et al.
Publicado: (2019)

Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB‐17 Fragment Library
por: Pujol‐Giménez, Jonai, et al.
Publicado: (2021)

Zip4 (Slc39a4) Expression is Activated in Hepatocellular Carcinomas and Functions to Repress Apoptosis, Enhance Cell Cycle and Increase Migration
por: Weaver, Benjamin P., et al.
Publicado: (2010)

The Zinc Transporter SLC39A14/ZIP14 Controls G-Protein Coupled Receptor-Mediated Signaling Required for Systemic Growth
por: Hojyo, Shintaro, et al.
Publicado: (2011)

Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa
por: Engelken, Johannes, et al.
Publicado: (2014)

Comparative Genomic Analysis of slc39a12/ZIP12: Insight into a Zinc Transporter Required for Vertebrate Nervous System Development
por: Chowanadisai, Winyoo
Publicado: (2014)

The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance
por: Verouti, Sophia N., et al.
Publicado: (2022)

Psychological stress induced zinc accumulation and up-regulation of ZIP14 and metallothionein in rat liver
por: Tian, Xue, et al.
Publicado: (2014)

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish
por: Janjuha, Sharan, et al.
Publicado: (2018)

Integrated analysis of transcriptomics, proteomics and metabolomics data reveals the role of SLC39A1 in renal cell carcinoma
por: Yuan, Yulin, et al.
Publicado: (2022)

The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways
por: Fukada, Toshiyuki, et al.
Publicado: (2008)

Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)
por: Meur, Gargi, et al.
Publicado: (2011)

AP-1 (bZIP) Transcription Factors as Potential Regulators of Metallothionein Gene Expression in Tetrahymena thermophila
por: de Francisco, Patricia, et al.
Publicado: (2018)

Role of Scl39a13/ZIP13 in cardiovascular homeostasis
por: Hara, Takafumi, et al.
Publicado: (2022)

The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis
por: Winslow, James W.W., et al.
Publicado: (2020)

Correction: The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways
por: Fukada, Toshiyuki, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_p3olceee00nvc0tif751u7ejnd