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Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138392/ https://www.ncbi.nlm.nih.gov/pubmed/21663703 http://dx.doi.org/10.1186/1756-6606-4-26 |
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author | Hasbi, Ahmed O'Dowd, Brian F George, Susan R |
author_facet | Hasbi, Ahmed O'Dowd, Brian F George, Susan R |
author_sort | Hasbi, Ahmed |
collection | PubMed |
description | Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance. |
format | Online Article Text |
id | pubmed-3138392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31383922011-07-19 Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance Hasbi, Ahmed O'Dowd, Brian F George, Susan R Mol Brain Review Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance. BioMed Central 2011-06-13 /pmc/articles/PMC3138392/ /pubmed/21663703 http://dx.doi.org/10.1186/1756-6606-4-26 Text en Copyright ©2011 Hasbi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Hasbi, Ahmed O'Dowd, Brian F George, Susan R Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance |
title | Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance |
title_full | Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance |
title_fullStr | Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance |
title_full_unstemmed | Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance |
title_short | Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance |
title_sort | dopamine d1-d2 receptor heteromer signaling pathway in the brain: emerging physiological relevance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138392/ https://www.ncbi.nlm.nih.gov/pubmed/21663703 http://dx.doi.org/10.1186/1756-6606-4-26 |
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