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Phospholipase Cζ binding to PtdIns(4,5)P(2) requires the XY-linker region

Phospholipase C-zeta (PLCζ) is a strong candidate for the mammalian sperm-derived factor that triggers the Ca(2+) oscillations required for egg activation at fertilization. PLCζ lacks a PH domain, which targets PLCδ1 to the phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) substrate in the pla...

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Detalles Bibliográficos
Autores principales:	Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian L., Nounesis, George, Swann, Karl, Lai, F. Anthony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Company of Biologists 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138701/ https://www.ncbi.nlm.nih.gov/pubmed/21730019 http://dx.doi.org/10.1242/jcs.083485

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