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Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

BACKGROUND: A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiovascular disorders associated with endothelial dysfunction. Novel sGC stimulators, including riociguat (BAY 63-2521), have a dual mode of action:...

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Detalles Bibliográficos
Autores principales:	Geschka, Sandra, Kretschmer, Axel, Sharkovska, Yuliya, Evgenov, Oleg V., Lawrenz, Bettina, Hucke, Andreas, Hocher, Berthold, Stasch, Johannes-Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138745/ https://www.ncbi.nlm.nih.gov/pubmed/21789188 http://dx.doi.org/10.1371/journal.pone.0021853

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