Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation

BACKGROUND: Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation. However, the role of Cdc42 in platelet activation remains controversial. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Akbar, Huzoor, Shang, Xun, Perveen, Rehana, Berryman, Mark, Funk, Kevin, Johnson, James F., Tandon, Narendra N., Zheng, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138762/
https://www.ncbi.nlm.nih.gov/pubmed/21789221
http://dx.doi.org/10.1371/journal.pone.0022117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138762/
https://www.ncbi.nlm.nih.gov/pubmed/21789221
http://dx.doi.org/10.1371/journal.pone.0022117

Ejemplares similares