Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis

Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing s...

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Detalles Bibliográficos
Autores principales: Park, Chang-Shin, Bochner, Bruce S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Continence Society 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138845/
https://www.ncbi.nlm.nih.gov/pubmed/21811694
http://dx.doi.org/10.5213/inj.2011.15.2.61
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author Park, Chang-Shin
Bochner, Bruce S.
author_facet Park, Chang-Shin
Bochner, Bruce S.
author_sort Park, Chang-Shin
collection PubMed
description Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed in mast cells could be evaluated as in vivo signaling regulators capable of inhibiting IC-related mast cell activation.
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spelling pubmed-31388452011-08-02 Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis Park, Chang-Shin Bochner, Bruce S. Int Neurourol J Review Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed in mast cells could be evaluated as in vivo signaling regulators capable of inhibiting IC-related mast cell activation. Korean Continence Society 2011-06 2011-06-30 /pmc/articles/PMC3138845/ /pubmed/21811694 http://dx.doi.org/10.5213/inj.2011.15.2.61 Text en Copyright © 2011 Korean Continence Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/ (http://creativecommons.org/licenses/by-nc/3.0) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Park, Chang-Shin
Bochner, Bruce S.
Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis
title Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis
title_full Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis
title_fullStr Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis
title_full_unstemmed Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis
title_short Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis
title_sort potential targeting of siglecs, mast cell inhibitory receptors, in interstitial cystitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138845/
https://www.ncbi.nlm.nih.gov/pubmed/21811694
http://dx.doi.org/10.5213/inj.2011.15.2.61
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