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The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects
PURPOSE: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. METHODS: In each animal, four circular calvarial defects...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Academy of Periodontology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139045/ https://www.ncbi.nlm.nih.gov/pubmed/21811687 http://dx.doi.org/10.5051/jpis.2011.41.3.123 |
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author | Chang, Yun-Young Dissanayake, Surangi Yun, Jeong-Ho Jung, Ui-Won Kim, Chang-Sung Park, Kyeong-Jun Chai, Jung-Kiu Choi, Seong-Ho |
author_facet | Chang, Yun-Young Dissanayake, Surangi Yun, Jeong-Ho Jung, Ui-Won Kim, Chang-Sung Park, Kyeong-Jun Chai, Jung-Kiu Choi, Seong-Ho |
author_sort | Chang, Yun-Young |
collection | PubMed |
description | PURPOSE: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. METHODS: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group). RESULTS: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing. CONCLUSIONS: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved. |
format | Online Article Text |
id | pubmed-3139045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Korean Academy of Periodontology |
record_format | MEDLINE/PubMed |
spelling | pubmed-31390452011-08-02 The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects Chang, Yun-Young Dissanayake, Surangi Yun, Jeong-Ho Jung, Ui-Won Kim, Chang-Sung Park, Kyeong-Jun Chai, Jung-Kiu Choi, Seong-Ho J Periodontal Implant Sci Research Article PURPOSE: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. METHODS: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group). RESULTS: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing. CONCLUSIONS: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved. Korean Academy of Periodontology 2011-06 2011-06-30 /pmc/articles/PMC3139045/ /pubmed/21811687 http://dx.doi.org/10.5051/jpis.2011.41.3.123 Text en Copyright © 2011 Korean Academy of Periodontology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/). |
spellingShingle | Research Article Chang, Yun-Young Dissanayake, Surangi Yun, Jeong-Ho Jung, Ui-Won Kim, Chang-Sung Park, Kyeong-Jun Chai, Jung-Kiu Choi, Seong-Ho The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects |
title | The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects |
title_full | The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects |
title_fullStr | The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects |
title_full_unstemmed | The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects |
title_short | The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects |
title_sort | biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139045/ https://www.ncbi.nlm.nih.gov/pubmed/21811687 http://dx.doi.org/10.5051/jpis.2011.41.3.123 |
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