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Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?

The c-AMP-responsive element binding protein (CREB) and its phosphorylated product (P-CREB) are nuclear proteins expressed after stimulation of pain-producing areas of the spinal cord. There is evidence indicating that central sensitization within dorsal horn neurons is dependent on P-CREB transcrip...

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Detalles Bibliográficos
Autores principales:	Mitsikostas, Dimos D., Knight, Yolande E., Lasalandra, Michele, Kavantzas, Nikolaos, Goadsby, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Milan 2011
Materias:	Original
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139063/ https://www.ncbi.nlm.nih.gov/pubmed/21626018 http://dx.doi.org/10.1007/s10194-011-0352-2

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