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Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation
Cell survival and apoptosis implicate an increasing complexity of players and signaling pathways which regulate not only the decision-making process of surviving (or dying), but as well the execution of cell death proper. The same complex nature applies to anoikis, a form of caspase-dependent apopto...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139189/ https://www.ncbi.nlm.nih.gov/pubmed/21785723 http://dx.doi.org/10.1155/2011/738137 |
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author | Vachon, Pierre H. |
author_facet | Vachon, Pierre H. |
author_sort | Vachon, Pierre H. |
collection | PubMed |
description | Cell survival and apoptosis implicate an increasing complexity of players and signaling pathways which regulate not only the decision-making process of surviving (or dying), but as well the execution of cell death proper. The same complex nature applies to anoikis, a form of caspase-dependent apoptosis that is largely regulated by integrin-mediated, cell-extracellular matrix interactions. Not surprisingly, the regulation of cell survival, apoptosis, and anoikis furthermore implicates additional mechanistic distinctions according to the specific tissue, cell type, and species. Incidentally, studies in recent years have unearthed yet another layer of complexity in the regulation of these cell processes, namely, the implication of cell differentiation state-specific mechanisms. Further analyses of such differentiation state-distinct mechanisms, either under normal or physiopathological contexts, should increase our understanding of diseases which implicate a deregulation of integrin function, cell survival, and anoikis. |
format | Online Article Text |
id | pubmed-3139189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31391892011-07-22 Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation Vachon, Pierre H. J Signal Transduct Review Article Cell survival and apoptosis implicate an increasing complexity of players and signaling pathways which regulate not only the decision-making process of surviving (or dying), but as well the execution of cell death proper. The same complex nature applies to anoikis, a form of caspase-dependent apoptosis that is largely regulated by integrin-mediated, cell-extracellular matrix interactions. Not surprisingly, the regulation of cell survival, apoptosis, and anoikis furthermore implicates additional mechanistic distinctions according to the specific tissue, cell type, and species. Incidentally, studies in recent years have unearthed yet another layer of complexity in the regulation of these cell processes, namely, the implication of cell differentiation state-specific mechanisms. Further analyses of such differentiation state-distinct mechanisms, either under normal or physiopathological contexts, should increase our understanding of diseases which implicate a deregulation of integrin function, cell survival, and anoikis. Hindawi Publishing Corporation 2011 2011-07-13 /pmc/articles/PMC3139189/ /pubmed/21785723 http://dx.doi.org/10.1155/2011/738137 Text en Copyright © 2011 Pierre H. Vachon. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Vachon, Pierre H. Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation |
title | Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation |
title_full | Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation |
title_fullStr | Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation |
title_full_unstemmed | Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation |
title_short | Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation |
title_sort | integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139189/ https://www.ncbi.nlm.nih.gov/pubmed/21785723 http://dx.doi.org/10.1155/2011/738137 |
work_keys_str_mv | AT vachonpierreh integrinsignalingcellsurvivalandanoikisdistinctionsdifferencesanddifferentiation |