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Task-Dependent and Independent Synchronous Activity of Monkey Hippocampal Neurons in Real and Virtual Translocation
Previous neurophysiological and behavioral studies relate hippocampal functions to place learning and memory, and encoding of task (or context)-specific information. Encoding of both task-specific information and own location is essential for episodic memory and for animals to navigate to reward-rel...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139221/ https://www.ncbi.nlm.nih.gov/pubmed/21808612 http://dx.doi.org/10.3389/fnbeh.2011.00036 |
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author | Hori, Etsuro Tabuchi, Eiichi Matsumura, Nobuhisa Ono, Taketoshi Nishijo, Hisao |
author_facet | Hori, Etsuro Tabuchi, Eiichi Matsumura, Nobuhisa Ono, Taketoshi Nishijo, Hisao |
author_sort | Hori, Etsuro |
collection | PubMed |
description | Previous neurophysiological and behavioral studies relate hippocampal functions to place learning and memory, and encoding of task (or context)-specific information. Encoding of both task-specific information and own location is essential for episodic memory and for animals to navigate to reward-related places. It is suggested that different neural circuits with different assemblies of different hippocampal neurons are created in different environments or behavioral contexts for the hippocampal formation (HF) to encode and retrieve episodic memory. To investigate whether synchronous activity of hippocampal neurons, suggesting functional connectivity between those neurons, is task and position dependent, multiple single unit activities were recorded during performance of real and virtual translocation (VT) tasks. The monkey moved to one of four reward areas by driving a cab (real translocation) or by moving a pointer on a monitor. Of 163 neuron pairs, significant peaks in cross-correlograms (CCGs) were observed in 98 pairs. Most CCGs had positive peaks within 50 ms. Task-dependent cross-correlations (CCRs) were observed in 44% of the neuron pairs, and similarly observed in both the real and VT tasks. These CCRs were frequently observed in pyramidal vs. pyramidal neuron pairs with positive peak and peak shift. However, no consistent patterns of peak polarity, peak shift, and neuronal types were seen in task-independent CCRs. There was no significant difference in frequency of CCG peaks between real and VT tasks. These results suggest that the task-dependent information may be encoded by interaction among pyramidal neurons, and the common information across tasks may be encoded by interaction among pyramidal neurons and interneurons in the HF. These neuronal populations could provide a neural basis for episodic memory to disambiguously guide animals to places associated with reward in different situations. |
format | Online Article Text |
id | pubmed-3139221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31392212011-08-01 Task-Dependent and Independent Synchronous Activity of Monkey Hippocampal Neurons in Real and Virtual Translocation Hori, Etsuro Tabuchi, Eiichi Matsumura, Nobuhisa Ono, Taketoshi Nishijo, Hisao Front Behav Neurosci Neuroscience Previous neurophysiological and behavioral studies relate hippocampal functions to place learning and memory, and encoding of task (or context)-specific information. Encoding of both task-specific information and own location is essential for episodic memory and for animals to navigate to reward-related places. It is suggested that different neural circuits with different assemblies of different hippocampal neurons are created in different environments or behavioral contexts for the hippocampal formation (HF) to encode and retrieve episodic memory. To investigate whether synchronous activity of hippocampal neurons, suggesting functional connectivity between those neurons, is task and position dependent, multiple single unit activities were recorded during performance of real and virtual translocation (VT) tasks. The monkey moved to one of four reward areas by driving a cab (real translocation) or by moving a pointer on a monitor. Of 163 neuron pairs, significant peaks in cross-correlograms (CCGs) were observed in 98 pairs. Most CCGs had positive peaks within 50 ms. Task-dependent cross-correlations (CCRs) were observed in 44% of the neuron pairs, and similarly observed in both the real and VT tasks. These CCRs were frequently observed in pyramidal vs. pyramidal neuron pairs with positive peak and peak shift. However, no consistent patterns of peak polarity, peak shift, and neuronal types were seen in task-independent CCRs. There was no significant difference in frequency of CCG peaks between real and VT tasks. These results suggest that the task-dependent information may be encoded by interaction among pyramidal neurons, and the common information across tasks may be encoded by interaction among pyramidal neurons and interneurons in the HF. These neuronal populations could provide a neural basis for episodic memory to disambiguously guide animals to places associated with reward in different situations. Frontiers Research Foundation 2011-07-14 /pmc/articles/PMC3139221/ /pubmed/21808612 http://dx.doi.org/10.3389/fnbeh.2011.00036 Text en Copyright © 2011 Hori, Tabuchi, Matsumura, Ono and Nishijo. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Neuroscience Hori, Etsuro Tabuchi, Eiichi Matsumura, Nobuhisa Ono, Taketoshi Nishijo, Hisao Task-Dependent and Independent Synchronous Activity of Monkey Hippocampal Neurons in Real and Virtual Translocation |
title | Task-Dependent and Independent Synchronous Activity of Monkey Hippocampal Neurons in Real and Virtual Translocation |
title_full | Task-Dependent and Independent Synchronous Activity of Monkey Hippocampal Neurons in Real and Virtual Translocation |
title_fullStr | Task-Dependent and Independent Synchronous Activity of Monkey Hippocampal Neurons in Real and Virtual Translocation |
title_full_unstemmed | Task-Dependent and Independent Synchronous Activity of Monkey Hippocampal Neurons in Real and Virtual Translocation |
title_short | Task-Dependent and Independent Synchronous Activity of Monkey Hippocampal Neurons in Real and Virtual Translocation |
title_sort | task-dependent and independent synchronous activity of monkey hippocampal neurons in real and virtual translocation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139221/ https://www.ncbi.nlm.nih.gov/pubmed/21808612 http://dx.doi.org/10.3389/fnbeh.2011.00036 |
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