Target-selective GABAergic control of entorhinal cortex output

The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We demonstrate that cannabinoid type-1 receptor-expressing GABAergic basket cells selectively innervate principal cells in layer II of the rat MEC that project outside the hippocampus, but avoid neighboring cells...

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Detalles Bibliográficos
Autores principales: Varga, Csaba, Lee, Soo Yeun, Soltesz, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139425/
https://www.ncbi.nlm.nih.gov/pubmed/20512133
http://dx.doi.org/10.1038/nn.2570
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author Varga, Csaba
Lee, Soo Yeun
Soltesz, Ivan
author_facet Varga, Csaba
Lee, Soo Yeun
Soltesz, Ivan
author_sort Varga, Csaba
collection PubMed
description The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We demonstrate that cannabinoid type-1 receptor-expressing GABAergic basket cells selectively innervate principal cells in layer II of the rat MEC that project outside the hippocampus, but avoid neighboring cells giving rise to the perforant pathway to the dentate gyrus. These results show that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.
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spelling pubmed-31394252011-07-19 Target-selective GABAergic control of entorhinal cortex output Varga, Csaba Lee, Soo Yeun Soltesz, Ivan Nat Neurosci Article The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We demonstrate that cannabinoid type-1 receptor-expressing GABAergic basket cells selectively innervate principal cells in layer II of the rat MEC that project outside the hippocampus, but avoid neighboring cells giving rise to the perforant pathway to the dentate gyrus. These results show that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons. 2010-05-30 2010-07 /pmc/articles/PMC3139425/ /pubmed/20512133 http://dx.doi.org/10.1038/nn.2570 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Varga, Csaba
Lee, Soo Yeun
Soltesz, Ivan
Target-selective GABAergic control of entorhinal cortex output
title Target-selective GABAergic control of entorhinal cortex output
title_full Target-selective GABAergic control of entorhinal cortex output
title_fullStr Target-selective GABAergic control of entorhinal cortex output
title_full_unstemmed Target-selective GABAergic control of entorhinal cortex output
title_short Target-selective GABAergic control of entorhinal cortex output
title_sort target-selective gabaergic control of entorhinal cortex output
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139425/
https://www.ncbi.nlm.nih.gov/pubmed/20512133
http://dx.doi.org/10.1038/nn.2570
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